Photo: Apollo 11 Moon Walk. Credit: NASAFROM: NASAHOUSTON -- A team of researchers at NASA's Johnson Space Center in
Houston and Lawrence Berkeley National Laboratory in Berkeley,
Calif., has found radiation from protons could further enhance a process that occurs during tumor progression. This information may help lead to better methods to protect astronauts from the harmful
effects of radiation in space, as well as help cancer researchers on Earth better understand the effects of radiation treatment on the
human body.
NASA is particularly interested in this research because protons, which are charged subatomic particles, are the main source of space
radiation astronauts receive during spaceflights. The study was part of NASA's ongoing effort to learn how to mitigate the effects of
radiation during long-duration missions to destinations beyond low Earth orbit, such as asteroids and Mars.
"Our paper makes new discoveries on the potential risks from low doses
of protons that occur outside of the tumor during radiation therapy,
and to all tissues for astronauts exposed to space radiation," said
Francis A. Cucinotta, chief scientist for the Human Research Program
Space Radiation Program Element at Johnson and one of the authors of
the paper.
The objective of the researchers was to study the biological effects
of low-energy protons on epithelial cells (membranous tissues found
throughout the body) and the protons' propensity to enhance a process
that occurs during tumor progression. This process is called
epithelial-mesenchymal transition (EMT), which has been associated
with cancer progression. EMT also has been linked to
radiation-induced fibrosis, one of the most common late effects of
radiotherapy.
Notably, the study revealed protons alone can induce EMT-associated
changes in normal human epithelial cells. Although the total body
dose received in space is moderately low compared to what is received
in radiotherapy, this study reveals that low doses of protons still
may prompt EMT and result in potentially detrimental effects.
These studies were conducted at Johnson and at the NASA Space
Radiation Laboratory at Brookhaven National Laboratory, Upton, N.Y.
Results of the study were published as "Protons Sensitize Epithelial
Cells to Mesenchymal Transition" in the July 23 issue of the journal
PLoS ONE.
