Thursday, April 25, 2013

THE PITCHER PLANT ECOSYSTEM

 
Pitcher Plant. Dept of the Interior, National Park Service
FROM: NATIONAL SCIENCE FOUNDATION

Earth Day: Big Ecosystem Changes Viewed Through the Lens of Tiny Carnivorous Plants

April 22, 2013

In one drop of water are found all the secrets of all the oceans.

---Kahlil Gibran

What do a pond or a lake and a carnivorous pitcher plant have in common?

The water-filled pool within a pitcher plant, it turns out, is a tiny ecosystem whose inner workings are similar to those of a full-scale water body.

Whether small carnivorous plant or huge lake, both are subject to the same ecological "tipping points," of concern on Earth Day--and every day, say scientists.

The findings are published in this week's issue of the journal Proceedings of the National Academy of Sciences.

In the paper, ecologists affiliated with the National Science Foundation (NSF) Harvard Forest Long-Term Ecological Research site in Massachusetts offer new insights about how such tipping points happen.

"Human societies, financial markets and ecosystems all may shift abruptly and unpredictably from one, often favored, state to another less desirable one," says Saran Twombly, program director in NSF's Division of Environmental Biology, which funded the research.

"These researchers have looked at the minute ecosystems that thrive in pitcher plant leaves to determine early warning signals and to find ways of predicting and possibly forestalling such 'tipping points.'"

Life in lakes and ponds of all sizes can be disrupted when too many nutrients--such as in fertilizers and pollution--overload the system.

When that happens, these aquatic ecosystems can cross "tipping points" and change drastically. Excess nutrients cause algae to bloom. Bacteria eating the algae use up oxygen in the water. The result is a murky green lake.

"The first step to preventing tipping points is understanding what causes them," says Aaron Ellison, an ecologist at Harvard Forest and co-author of the paper. "For that, you need an experiment where you can demonstrate cause-and-effect."

Ellison and other scientists demonstrated how to reliably trigger a tipping point.

They continually added a set amount of organic matter--comparable to decomposing algae in a lake--to a small aquatic ecosystem: the tiny confines of a pitcher plant, a carnivorous plant native to eastern North America.

Each pitcher-shaped leaf holds about a quarter of an ounce of rainwater. Inside is a complex, multi-level food web of fly larvae and bacteria.

"The pitcher plant is its own little ecosystem," says Jennie Sirota, a researcher at North Dakota State University and lead author of the paper.

Similar to lake ecosystems, oxygen levels inside the water of a pitcher plant are controlled by photosynthesis and the behavior of resident organisms--in this case, mostly bacteria.

Ellison says that conducting an experiment with bacteria is like fast-forwarding through a video.

"A bacterial generation is 20 minutes, maybe an hour," he says. "In contrast, fish in a lake have generation times of a year or more.

"We would need to study a lake for 100 years to get the same information we can get from a pitcher plant in less than a week."

The same mathematical models, Ellison and colleagues discovered, can be used to describe a pitcher plant or a lake ecosystem.

To approximate an overload of nutrients in pitcher-plant water, the team fed set amounts of ground-up wasps to the plants.

"That's equivalent to a 200-pound person eating one or two McDonald's quarter-pounders every day for four days," says Ellison.

In pitcher plants with enough added wasps, an ecosystem tipping point reliably occurred about 45 hours after the start of feeding.

The scientists now have a way of creating tipping points. Their next step will be to identify the early warning signs.

"Tipping points may be easy to prevent," says Ellison, "if we know what to look for."

Other authors of the paper are Benjamin Baiser of Harvard Forest and Nicholas Gotelli of the University of Vermont.

-NSF-

SECREATY HAGEL VISITS JORDAN

FROM:  U.S. DEPARTMENT OF DEFENSE
Places Jordan Among Most Important Middle East Partners
By Cheryl Pellerin
American Forces Press Service

AMMAN, Jordan, April 23, 2013 - Defense Secretary Chuck Hagel met here today with Jordan's Lt. Gen. Prince Faisal bin Al Hussein and Gen. Mashal al-Zaben, chairman of the Joint Chiefs of Staff of the Jordanian armed forces, Pentagon Press Secretary George Little said in a statement.

The United States and Jordan -- which Hagel said is one of the most important U.S. partners in the region -- share concerns about the crisis in Syria and continue to consult closely on issues including chemical weapons and demands posed by the influx of Syrian refugees fleeing the violence, Little added.

During the meeting, Hagel reaffirmed the closeness of the U.S.-Jordan strategic relationship and reiterated the DOD commitment to working with the Jordanian armed forces to address common challenges, the press secretary said.

The leaders discussed Hagel's decision, announced April 17, to sustain U.S. military personnel in Jordan to foster even closer planning, improve joint readiness, and prepare for a range of scenarios, Little noted.

Hagel and Army Gen. Martin E. Dempsey, chairman of the Joint Chief of Staff, reported to the Senate Armed Services Committee that the secretary ordered the Army deployment to help Jordanian forces defend their border with Syria. The contingent will enhance the efforts of a small U.S. military team that has been working in Jordan since last year on planning related to chemical weapons and preventing a spillover of violence across Jordan's borders, Hagel told the Senate panel.

DOD personnel and interagency partners are helping Jordan, Turkey, Iraq and other Syrian neighbors counter the threat posed by Syria's chemical weapons, Hagel said during the hearing.

The secretary, Prince Faisal and Zaben agreed to continue to work closely together to support mutual objectives, develop capacity and provide military assistance as needed to the Jordanian armed forces, Little said.

Hagel commended Jordan on its decision to keep borders open to refugees fleeing the violence in Syria, the press secretary said, adding that Jordan now hosts nearly 500,000 Syrian refugees.

In addition to about $409 million in humanitarian assistance the United States has provided to those affected by the violence in Syria, Little said, DOD has provided more than $1.2 million in goods such as food, water, medical supplies and power generators through the Jordanian armed forces to help in the care and transport of refugees coming across the border.

DOD also has provided more than $70 million to Jordan this year to help secure its borders and prevent chemical-weapons transfer, Little said.

Hagel's trip to the Middle East, which began April 20 and will end April 26, also will take the secretary to Saudi Arabia, Egypt and the United Arab Emirates to discuss common threats and interests in the region.

Weltraumschrott: Internationale Experten einig über dringenden Handlungsbedarf

Weltraumschrott: Internationale Experten einig über dringenden Handlungsbedarf

HHS HAS APP FOR MANAGEMENT OF RISK FOR HEART DISEASE

Photo:  Mobile App.  Credit:  HHS
FROM: U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES

From the U.S. Department of Health and Human Services, I’m Nicholas Garlow with HHS HealthBeat.

Your health is going digital. Health applications on the go are becoming more available. The HHS initiative, Million Hearts, recently challenged developers to create an app that helps people manage their heart health.

Dr. Simon Lin and his team at the Marshfield Clinic Research Foundation did just that.

"Just as we need motivation to exercise and to eat healthy food, we also need those easy-to-use tools to track our health goals."

The Heart Health Mobile app helps you manage your risk of heart disease.

HHS has also developed numerous apps around heart health, weight, women’s health, and more. You can find the full list of HHS apps on
hhs.gov/digitalstrategy.

HHS HealthBeat is a production of the U.S. Department of Health and Human Services. I’m Nicholas Garlow.

Last revised: April 21, 2013

Precisa-se de médico para missão na Antártida

Precisa-se de médico para missão na Antártida

Press Briefing | The White House

Press Briefing | The White House

TESTIMONY BEFORE HOUSE FOREIGN AFFAIRS COMMITTEE ON EXPORT CONTROL REFORM

FROM: U.S. DEPARTMENT OF STATE
Export Control Reform: The Agenda Ahead

Testimony
Thomas Kelly
Acting Assistant Secretary, Bureau of Political-Military Affairs
Statement Before the House Foreign Affairs Committee Hearing on Export Control Reform
Washington, DC
April 24, 2013


I thank the Chairman for his introduction, and would ask that my written remarks be entered into the record.

Chairman Royce, Congressman Sherman, Committee Members: it has been two years since the Committee last met to hear testimony on the President’s Export Control Reform Initiative. A lot of work has been done in the intervening period. I would like to start by thanking thw Committee on behalf of the State Department for its bipartisan support throughout the process.

As the pace of technological advance accelerates, and as technological capability spreads around the world, the need to update our Export Controls is increasingly urgent. We are no longer in an era in which a handful of countries hold the keys to the most sensitive technologies, as was the case during the Cold War. Today, a whole range of nations have advanced technological capability.

At the same time, because of the diffusion of technology, many U.S. companies must collaborate with foreign partners to develop, produce and sustain leading-edge military hardware and technology. Their survival depends on it.

But because our current export controls are confusing, time-consuming, and – many would say-- overreaching, our allies increasingly seek to ‘design out’ US parts and services, thus avoiding our export controls and the end-use monitoring that comes with them in favor of indigenous design. This threatens the viability of our defense industrial base, especially in these austere times.

Our current system has another problem. It can prevent our allies in theatre from getting the equipment and technology they need to fight effectively alongside our troops in the field.

This system has its basis in the 1960s, and has not undergone significant update since the early 1990s. It is cumbersome, complex and incorrectly controls too many items as though they were "crown jewel" technologies.

What that has meant is that an inordinate amount of agencies’ resources – both in terms of licensing and compliance activities – has been expended on nuts and bolts as well as our REAL "crown jewel" technologies.

In November 2009, President Obama directed a White House task force to identify how to modernize our export control system so that it will address the current threats we face, as well as account for the technology and economic landscape of the 21st century.

His direction was grounded in national security, with the goal of putting up ‘higher fences’ around the items that deserve the greatest protection, while permitting items of lesser sensitivity to be exported more readily when appropriate.

To address the problems the task force identified, they recommended reforms in four key areas: licensing policies and procedures; control lists; information technology; and export enforcement.

The President accepted the recommendations, and since early 2010, agencies have been working hard to implement them.

Much of agencies’ efforts have centered on revising the U.S. Munitions List and the Commerce Control List. This reform will draw a "bright line" between the two lists using common terms and control parameters. This will help our exporters determine far more easily which list their products are on. The reform will ensure that those items of greatest concern to us from a national security and foreign policy perspective will remain on the USML, and thus be subject to the most stringent licensing requirements, while items of less sensitivity will be moved to the CCL.

I want to emphasize a key point: items moving to the CCL are going to remain controlled. They are not being "decontrolled", but in specific circumstances, they will be eligible for export under Commerce’s more flexible licensing mechanisms.

I am confident that the revised lists will permit State to continue to perform its national security and foreign policy mandates in export licensing.

I will also note that we are making tremendous progress in the effort to rewrite the categories. We have published twelve rebuilt USML categories in the Federal Register for public comment. The proposed rules for the seven remaining categories have been drafted and are either undergoing or awaiting interagency review so that we can then publish them for public comment.

On April 16, the Departments of State and Commerce published companion rules that implement the revised USML Categories VIII (Aircraft) and XIX (Engines). This is the first pair in a series of final rules that put in place the rebuilt export control lists. Our goal is to publish the revised USML in its entirety on a rolling basis throughout this year.

In the last phase of our reform effort, we will need legislation to bring the initiative to its logical conclusion by creating a single licensing agency. The Administration has not yet determined when to approach this effort, but we will fully engage our oversight Committees and know that we can count on your support when we do.

On that note, one final point I want to make is that this has not only been an interagency process, but a cross-government process. Over the course of the last three years, we have had the opportunity to work closely with this Committee, and with many others across the Congress, on both the broader strategic questions of national security, and the finer technical details of our proposals. Our work together shows what we can achieve together. I am grateful for your bipartisan support for this initiative and look forward to continuing to work closely with you on the remainder of the reform effort.

With that, I want to thank you for inviting me to testify. I now would like to turn the floor over to Commerce Assistant Secretary Kevin Wolf.

 

 

RALPH LAUREN CORPORATION SETTLES FCPA ALLEGTIONS WITH JUSTICE DEPARTMENT

FROM: U.S. DEPARTMENT OF JUSTICE
Monday, April 22, 2013

Ralph Lauren Corporation Resolves Foreign Corrupt Practices Act Investigation and Agrees to Pay $882,000 Monetary Penalty

Ralph Lauren Corporation (RLC), a New York based apparel company, has agreed to pay an $882,000 penalty to resolve allegations that it violated the Foreign Corrupt Practices Act (FCPA) by bribing government officials in Argentina to obtain improper customs clearance of merchandise, announced Mythili Raman, the Acting Assistant Attorney General for the Criminal Division, and Loretta E. Lynch, the United States Attorney for the Eastern District of New York.

According to the agreement, the manager of RLC’s subsidiary in Argentina bribed customs officials in Argentina over the span of five years to improperly obtain paperwork necessary for goods to clear customs; permit clearance of items without the necessary paperwork and/or the clearance of prohibited items; and on occasion, to avoid inspection entirely. RLC’s employee disguised the payments by funneling them through a customs clearance agency, which created fake invoices to justify the improper payments. During these five years, RLC did not have an anti-corruption program and did not provide any anti-corruption training or oversight with respect to its subsidiary in Argentina.

In addition to the monetary penalty, RLC agreed to cooperate with the Department of Justice, to report periodically to the department concerning RLC’s compliance efforts, and to continue to implement an enhanced compliance program and internal controls designed to prevent and detect FCPA violations. If RLC abides by the terms of the agreement, the Department will not prosecute RLC in connection with the conduct.

The agreement acknowledges RLC’s extensive, thorough, and timely cooperation, including self-disclosure of the misconduct, voluntarily making employees available for interviews, making voluntary document disclosures, conducting a worldwide risk assessment, and making multiple presentations to the Department on the status and findings of the internal investigation and the risk assessment. In addition, RLC has engaged in early and extensive remediation, including conducting extensive FCPA training for employees worldwide, enhancing the company’s existing FCPA policy, implementing an enhanced gift policy and other enhanced compliance, control and anti-corruption policies and procedures, enhancing its due diligence protocol for third-party agents, terminating culpable employees and a third-party agent, instituting a whistleblower hotline, and hiring a designated corporate compliance attorney.

In a related matter, the U.S. Securities and Exchange Commission today announced a non-prosecution agreement with RLC , in which RLC agreed to pay $$734,846 in disgorgement and prejudgment interest.

The case is being prosecuted by Trial Attorney Daniel S. Kahn of the Criminal Division’s Fraud Section and Sarah Coyne, Chief of the Business and Securities Fraud Section of the Eastern District of New York. The case was investigated by the FBI’s New York Field Office. The department acknowledges and expresses its appreciation for the assistance provided by the SEC’s Division of Enforcement.

DEFENSE SECRETARY MEETS WITH SAUDI DEPUTY DEFENSE MINISTER


Defense Secretary Chuck Hagel meets with Saudi Arabia's Prince Fahd bin Abdullah, the country's deputy defense minister, for a welcoming tea ceremony in Riyadh, Saudi Arabia, April 23, 2013. Hagel is on a six-day trip to the Middle East, where he is visiting counterparts in Israel, Jordan, Saudi Arabia, Egypt and the United Arab Emirates. DOD photo by Erin A. Kirk-Cuomo
FROM: U.S. DEPARTMENT OF DEFENSE

Hagel: Defense Partnership Anchors U.S.-Saudi Relationship
By Cheryl Pellerin
American Forces Press Service

RIYADH, Saudi Arabia, April 23, 2013 - On his inaugural trip to the Middle East since taking office, Defense Secretary Chuck Hagel met here today with Saudi Crown Prince and Defense Minister Salman bin Abdulaziz Al Saud, Pentagon Press Secretary George Little said in a statement.

During their talks, Hagel and his Saudi counterpart reiterated the longstanding, steadfast relationship between the United States and Saudi Arabia, and emphasized the strong defense partnership that anchors the two nations, Little added.

They also discussed the release of standoff weapons to Saudi Arabia that will provide strategic precision defensive capabilities to the Saudi F-15 fleet, Little said. Such smart weapons can navigate to their targets and are more precise and can be fired at further distances.

"Both agreed the release reflected the close bilateral partnership and would enable long-term cooperation in the pursuit of common security policy aims of a peaceful and stable region," Little said. The two defense leaders also consulted on regional issues, including the need for Iran to abide to international commitments on its nuclear program, the situation in Syria, and the political transition in Yemen, he added.

Hagel's trip to the Middle East, which began April 20 and will end April 26, began in Israel and Jordan and tomorrow will take the secretary to Egypt and the United Arab Emirates to discuss common threats and interests in the region.

Wednesday, April 24, 2013

DVIDS - Video - DARPA Briefing

DVIDS - Video - DARPA Briefing

U.S. Department Of State Daily Press Briefing - April 24, 2013

Daily Press Briefing - April 24, 2013

ISAF NEWS FROM AFGHANISTAN

 
U.S. Army 1st Lt. Robert Wolfe scans for security threats from a rooftop during a meeting with the Farah provincial council at the governor's compound in Farah City, Afghanistan, April 18, 2013. Wolfe, a platoon leader, is assigned to Provincial Reconstruction Team Farah. U.S. Navy photo by Chief Petty Officer Josh Ives


FROM: U.S. DEPARTMENT OF DEFENSE

Combined Security Force Kills Insurgents in Helmand Province

From an International Security Assistance Force Joint Command News Release

KABUL, Afghanistan, April 24, 2013 - A combined Afghan and coalition security force killed two insurgents during a search for a Taliban leader in the Nad-e Ali district of Afghanistan's Helmand province yesterday, military officials reported.

The leader is believed to be responsible for purchasing and distributing improvised explosive device components to other Taliban members. He also has participated in attacks against Afghan and coalition forces and provides intelligence to senior Taliban leaders in the province, officials said.

In other Afghanistan operations yesterday:

-- A combined force in Helmand's Nahr-e Saraj district killed an insurgent during a search for a Taliban leader who is believed to oversee IED operations in the district. He also has participated in assassinations against Afghan national security force members and provided intelligence to senior Taliban leaders.

-- Afghan Provincial Response Company Zabul, enabled by coalition forces, detained several insurgents and seized and destroyed 132 pounds of ammonium nitrate aluminum powder in Zabul province's Shinkay and Qalat districts. Insurgents use the powder in making IEDs.

U.S.S HOON ARRIVES IN VEITNAM AND USS JOHN C. STENNIS RETURNS TO PEARL HARBOR-HICKAM BASE




FROM: U.S. NAVY 

Sailors aboard the guided-missile destroyer USS Chung Hoon (DDG 93) shift colors after arriving in Da Nang, Vietnam, for a naval engagement activity. The engagement provides opportunities for U.S. and Vietnamese naval professionals to share best practices and exchange maritime skills in humanitarian assistance and disaster relief, medical training, fire fighting and damage control, search and rescue, diving and salvage, sports and community service projects. U.S. Navy photo by Mass Communication Specialist 1st Class Jay C. Pugh (Released) 130421-N-YU572-057




The aircraft carrier USS John C. Stennis (CVN 74) enters Joint Base Pearl Harbor-Hickam as friends and family members of Sailors greet them from shore. The John C. Stennis Carrier Strike Group is returning from an eight-month deployment conducting operations in the U.S. 5th and 7th Fleet areas of responsibility. U.S. Navy Photograph by Mass Communication Specialist 2nd Class Daniel Barker (Released) 130421-N-RI884-070.

 

President Obama Meets with the Amir of Qatar | The White House

President Obama Meets with the Amir of Qatar | The White House

GENERAL POLUMBO OUTLINES FUTURE MISSION IN AFGHANISTAN

FROM: U.S. DEPARTMENT OF DEFENSE 

Presenter: Director, ISAF Air Component Coordination Element and Commander, 9th Air and Space Expeditionary Task Force-Afghanistan Major General H.D. Polumbo Jr.
 
April 23, 2013

Department of Defense Press Briefing with Maj. Gen. Polumbo from the Pentagon Briefing Room
COMMANDER BILL SPEAKS: Good morning here in the Briefing Room, and good afternoon in Kabul, Afghanistan. I'd like to welcome Major General H.D. Polumbo, Jr., to the Pentagon Briefing Room.

Major General Polumbo is commander of the 9th Air and Space Expeditionary Task Force in Afghanistan. He oversees three air expeditionary air wings and two expeditionary groups, consisting of more than 450 airmen directly engaged in combat operations, and he advises and assists with joint expeditionary tasked individuals in the Afghanistan Combined/Joint Operations Area.

Additionally, the general serves as the Central Command coalition air component commander's personal representative to the commander of headquarters ISAF, as well as the deputy commander for air to the commander of U.S. forces in Afghanistan, ensuring the optimal integration of air and space power and supports headquarters ISAF and Operation Enduring Freedom missions.

This is Major General Polumbo's first time here with us in the Pentagon Briefing Room. He will provide brief opening remarks and take your questions.

And with that, sir, I'll turn it over to you.

MAJOR GENERAL H.D. POLUMBO JR.: Hey, Cmdr. Speaks, thank you. Good morning, everybody there at Washington and good evening from over here in Kabul, Afghanistan. I'm Jake Polumbo and would let you all know that it's been my distinct honor, actually, to serve as the senior NATO and U.S. airman here in Afghanistan for the last year. And I'll take the next 30 minutes or so, or as long as you need to -- and welcome the opportunity to share some of my recent experiences with all of you as this campaign here in Afghanistan enters a new phase. And that phase is Afghans taking the lead for their own security and ISAF stepping back into a supporting role.

Throughout this campaign, coalition airpower has provided a critical asymmetric advantage over those who threaten the security of Afghanistan. And air will continue to do so for the remainder of the ISAF campaign, I'm confident. But in the weeks to come, our focus is going to shift -- will shift to supporting the Afghan national security forces, and I will continue to emphasize the Afghan Air Force, so that the core commanders, the ground commanders can hold and expand on the significant security gains they've made that were enabled by NATO forces.

You all can imagine that building an air force from the ground up is no easy task. It takes skilled, confident, bold air crews, proud maintenance specialists who have the technical expertise and language skills needed to operate and maintain their aircraft through a variety of challenging roles and missions of the Afghan air force and in the rugged terrain found here in Afghanistan.

Austere conditions, challenging weather patterns, remote locations, and combat conditions only increase the degree of difficulty of these tasks, but the Afghans -- and particularly the Afghan airmen -- are hardy people and have eagerly embraced these challenges.

The results are showing not only in the training environment, but more importantly on the battlefield. And Afghan air force airmen have conducted winter resupply missions to remote Afghan National Army locations in Nuristan Province in the east, and they've provided direct support to Afghan border police in Paktika, Zabul Province in the east, and also down in the south, in Kandahar Province.

During recent combat operations, Afghan air force helicopters flew life-saving casualty evacuation flights, and they also conducted independent air assaults into contested areas. Admittedly, Afghan air force capacity is still very limited, and it'll need continued assistance from NATO to increase their capabilities to conduct missions like air surveillance, air support, and mobility operations, and the like.

But the early signs are, indeed, encouraging, and continued Afghan air force development will bolster the confidence of the rest of the Afghan security forces as they increasingly meet their specific security needs with their own organic capabilities.

As we assist the Afghans in developing their own organic military capabilities, our proven coalition airpower will provide vital protection -- force protection and sustainment for the NATO force, even as we set the theater for the end of the ISAF mission in December 2014 and transitioned to the anticipated NATO resolute support mission during the decade of opportunity.

In the new NATO mission, we'll work -- continue to work side by side with our Afghan partners to achieve some mutual goals. And those goals include the following: a competent, self-reliant Afghan national security force; an operationally ineffective al-Qaeda deprived of safe havens from which to conduct their operations; an acceptable political transition defined by free and fair elections next year; and, finally, improved regional security relationships between Afghanistan and our neighbors, in particular Pakistan.

The ISAF commander is confident these goals are achievable, but he also reminds us, his staff, every day that they're not inevitable. A firm commitment to these objectives is necessary to achieve a positive result for the Afghan people and the air component, the airmen that I work with every day will always be ready to do their part.

It's been an honor to command the truly remarkable airmen in our U.S. and coalition air forces in Afghanistan and continue our vital air mission in support of the ground commanders. With that, ladies and gentlemen, I'd be glad and happy to take any of your questions.

CMDR. SPEAKS: Spencer?

Q: Thank you, General Polumbo. Spencer Ackerman with Wired. I'm hoping we can quantify some of the aspects of the air operations you've talked about. What percentage of air assault missions are being conducted solely by the Afghan national security forces' air components? We hear a lot about the size of the ANSF on the ground. What still remains to be done in terms of the size of the ANSF air presence, both in terms of personnel and also in terms of the actual air fleet, the aircraft that it still needs?

MAJ. GEN. POLUMBO: Yeah, Spencer, that's a great question. And to be -- to put it into macro terms for you, as we drive the Afghan national security force towards their number, their sustained number of over 350,000 troops, only 6,000 or so right now are in the Afghan air force.

And so you can imagine that the percentage of Afghan air force support forward is small, and that's okay, because what truly is happening now is we assist the Afghan security forces, the core commanders, the kandak commanders, we assist them with all of our sustainment capabilities that we have, which is very robust. Our NATO forces are very capable.

And so it's a small percentage that the Afghan air force supplies, in terms of resupply missions, in terms of their other ways to connect the kandaks to the battle space, but over the next two years, it will increase. And, again, this is what's so important to me as an airman, is there is a pipeline for increased capacity with the air crew members, the pilots, copilots, the load masters, the crew chiefs, as those increase the ability to -- and capacity will increase for them to resupply their own ground operations.

Q: About the air assault, what percentage of air operations right now are conducted by the ANSF air force independently?

MAJ. GEN. POLUMBO: Again, it's a small percentage. And I can get you those numbers and would be happy to do that. It's a small percentage where their air assault is done -- they have more than just the Afghan air force air wings that they have at their locations. They have a special mission wing that also, with Mi-17 helicopters, is able to provide lift for their helicopter assault force, or assault forces, into specific regions in -- in the east primarily.

So -- but it's a very small number, and that's where you need to understand that many of the movements that the Afghans will make will be by -- by land, by ground capabilities, and then when they need those specific assaults that are done into the mountainous regions, with their Mi-17s either in the Afghan air force or in the special mission wing, that they plan those, they prioritize those, they make them, you know, work in terms of how the ground forces command prioritizes those events day by day.

Q: Do they have any close air support capabilities?

MAJ. GEN. POLUMBO: They don't. And, again, another good question in the sense of where are the gaps that they have currently in their arsenal, in their quiver, if you will, for how they can do combined operations. What they do have are they -- they have six Mi-35 helicopters that have forward-firing capability, and that capability from my standpoint as the senior airman here is designed to primarily start to set the tactics, the techniques, and the procedures, as we call them, the TTPs, for how they will bring on the Super Tucano now, which is the selected aircraft that the Afghan air force will have that will have multiple capabilities, multiple weapons, weapons capabilities.

And so these Mi-35s that they have that they're now currently flying -- and actually have used in some combat operations in rocket boxes and different things around the Kabul area -- they will set those TTPs up that will allow then these Super Tucanos -- or as I will designate them, the A-29 -- to come into the inventory, starting within the next year, and then probably fully operational into the 2015 timeframe.

So you can see your -- as your question alludes to, they have no close air support capability as we would define it, as NATO coalition. What they will have is the air support that their -- their ground commanders will need, and in particular, when this A-29 comes onboard, a very, very good and robust capability, as the numbers come onboard.

CMDR. SPEAKS: Lalit?

Q: Yeah, thank you, General, for doing this. Can you give us a sense into what's a timeline or a strategy for having a strong and independent Afghan air force? And would -- you will be providing any kind of support to the Afghan national security forces post-2014? Because they will need air support for their combat operations.

MAJ. GEN. POLUMBO: Yes, I'd be happy to do that. And as you allude to, it will take time for the Afghan air force to end up as a fully operational -- full operational capability, as we call it, FOC, and that will take into the 2016, end of 2016 timeframe at best, and we understand that. That is -- that is exactly how we have partnered with the Afghan security forces, in particular the air force, is to be committed to that duration and to bring on these aircraft, these training mechanisms, and the like.

MAJ. GEN. POLUMBO: In the meantime, what the ISAF mission will do -- and NATO coalition air will do -- will be to provide support when our commanders, when our coalition commanders deem it required in order to assist the Afghan ground commanders with the operations that are -- that are undergoing -- they're -- that they're undertaking.

So we have what I would call -- and as the senior airmen have coined the phrase -- a graduated approach for how our forces would put air support into the equation to assist our Afghan ground commanders with their contact with the insurgents. And that graduated approach is a very detailed way -- we have a specific standard operating procedure as to how our regional commanders interact with the core commanders, and the primary way that we emphasize it is to start out with what they have organic, their mortars, their D-30 mortars, their D-60 mortars that are coming online, their indirect fire capability, where we, with a graduated approach mindset, will assist them with information, with intelligence, with targeting options to try and make sure they understand, once they are in contact with the enemy, with the insurgents, where are they exactly? How would they best target them with what they have organic?

And then if they need to, and they need to step it up because the conditions are worsening, then we would move towards something that they would have in their capability like attack helicopters, because the Mi-35 is there. At some point in time, we'll have door gunners in the Mi-17s. So we would provide, as we graduate this assistance, if, in fact, our coalition commanders deem that appropriate, we would assist with those types of -- of helicopter assault force, those things.

And in the most significant or dire of circumstances, if you will, in a very -- what we would call in extremis situation, when senior commanders in the ISAF headquarters deem it appropriate, we would put the absolute finest capable platforms we have, what I call our national unique platforms, in play, and then with our coalition commanders controlling those strikes, we would assist the Afghans in that regard.

There's no doubt that General Dunford and COMISAF, our commander, has told us, we -- we will assist them to make sure that there are no significant setbacks in this campaign, but we have to use a graduated approach so that they continue to learn how to fight with what they'll have in their own arsenal.

Q: General, Otto Kreisher with Seapower Magazine. There's been a lot of talk about the downsizing, drawback of the ground forces, ISAF ground forces, because the -- it's going to take so long for the ASFN to develop their air component, is -- what's the -- how are you planning to draw down an air asset? And, you know, based in Afghanistan, using Navy -- naval assets offshore, how -- how does that schedule play out? Are you going to need to keep air assets in at a higher level perhaps than -- than the ground?

MAJ. GEN. POLUMBO: Yeah, Otto, you're read-in very good -- very well on this. And, again, you've mentioned a couple things that -- if you'll permit me, I'll walk you through this. First and foremost, we know that air is a critical enabler in many of the operations that we do, that coalition ground forces do in partner with our Afghan security forces and sometimes on our own.

But as I've said in my opening statement, those coalition operations where we are out in the lead of anything are scaling back and moving into the background so that we can advise and assist, as we finish up the ISAF mission over the next 20 months.

But air will always be important in that regard. It's our asymmetric advantage. The insurgents, the Taliban have no match to it, and therefore we always have that ability to provide that force protection, to provide that capability to pack that punch that really keeps them on their heels, if not just in retreat.

So how do we then work that into, you know, the next year with respect to the Afghans? Well, again, it's that graduated approach. But the drawdown to our enduring presence numbers is underway. And we certainly have our guidance in the U.S., and the other NATO nations are similarly working their way down towards the numbers that will be here at the end of '14, which we'll call the enduring presence numbers.

How will air draw down according to COMISAF and COMIJC? It will draw down at a slower rate, at a slower -- at a less severe of a slope in order to maintain that asymmetric advantage. In my view, we need to make sure that we keep our intelligence, our surveillance, our reconnaissance capabilities fairly high, especially through the end of this fighting cycle, end of this year, and into the election period next year, which is so critical to the success of this campaign, is to enable the Afghans to have a free and fair election.

So we will draw down at slightly slower -- lower slope, but we'll ultimately -- as we get to the enduring presence numbers -- end up with a smaller air component in Afghanistan to transition to resolute support.

But you -- you rightfully remind our viewers and the rest of the reporters that there's over-the-horizon capability. And the air component -- specifically, the key nations that contribute to air and very much so the U.S. -- keeps a very capable over-the-horizon component that can be called in by the commander of U.S. Forces Afghanistan/the commander of ISAF, General Dunford, as the same person, and I, as the senior airman, along with the CFAC back in -- in the CAOC at Al Udeid, we worked that day in and day out via an air tasking order that allows us to flex whenever the situation requires. So the drawdown a little bit slower, and we have over-the-horizon capabilities that can be called back into the equation very quickly. Very good question, though.

CMDR. SPEAKS: Kristina?

Q: Hi, General, this is Kristina Wong from the Washington Times. Thanks so much for speaking with us this morning. My first question is, could you talk a little bit more about the challenges of illiteracy and just some challenges in training pilots, maintenance crews, and -- and just across the board what kind of challenge that is?

And then, also -- and I've heard estimates of, you know, an air -- Afghan air force standing up, you know, in 2018. You mentioned 2016 at best. And I was wondering, you know, how many trainers you have now and how many trainers you envision sort of having post-2014 throughout 2018?

MAJ. GEN. POLUMBO: First, to the illiteracy question, I continue to emphasize to my commanders in the coalition and also to the commanders in the Afghan security forces, and particularly my good friend, Major General Wahab, the commander of the air force, Afghan air force, that the literacy piece is so important, and the ability to read and write and communicate in English is critical to the development -- further development of the Afghan air force.

And because of that, two things have happened. One is that the chief of general staff has agreed to higher accession standards for the Afghan air force, and they are slowing working those procedures into their recruitment and pipeline process, so that the air force gets the recruits that can begin this higher-tech training that's required to fix the aircraft, to fly the aircraft, to crew chief the aircraft, et cetera, and then to be able to operate (inaudible) dynamic combined arms setting.

It isn't there yet. They will sometimes in our monthly recruiting results will end up with a class that comes in and their literacy rates are too low and their English skills are not where they need to be, and we will turn those recruits away, and they will go back into kind of a general fund, if you will, and go into other things.

So we'll continue to highlight that, because it can't happen. You know, a Super Tucano and different types of airplanes, the Cessna 208, the Mi-17V5, which is a very capable airplane for flying in Afghanistan, a helicopter, it requires English and full literacy capabilities. So I will stay on that, and we will stay on it.

In terms of the number of trainers, it's actually a very small number in the 300 or so -- and you -- I can get you more exact numbers, but it's a very small portion of the total advise and assist footprint that is in the coalition force management level.

And I anticipate it won't get any bigger than that in 2014 into '15, because we have -- as I've said, we have a training pipeline that has the strategic goals in mind to get the capability and capacity up between 2015, 2016, and then finishing in '17. So, again, the numbers will be small in comparison to the advisers and the people who will -- the troops that will provide assistance to the army and to the police.

CMDR. SPEAKS: Richard?

Q: Sir, Richard Sisk of Military.com. Another numbers question. Sir, can you tell us how many sorties the ISAF forces have flown this year in which the aircraft have fired or dropped munitions? And how does that stack up against previous years?

MAJ. GEN. POLUMBO: Yeah, Richard, good question. And I can get those numbers to you. You know, my last monthly report to the commander had over 11,000 sorties flown by all of the coalition, including the sorties that come in from over-the-horizon, so it's a very, very high number of sorties that are flown, but you can imagine that a lot of that is the re-supply, intra-theater lift. A lot of that is the different helicopter ops and everything else.

That's why I say, if you can be more specific, I can get you very precise answers, and I'd be happy to do that for you, because we're very proud of the fact that we fly an incredible amount of rotary wing and fixed-wing sorties every day and night, 365 days. We get absolute incredible support from over-the-horizon, whether it's from the carrier strike group or from the bases in the Arabian Gulf.

In -- in the particular piece of kinetic deliveries, it's a very small percentage of that, a significantly small percentage, because we don't go kinetic very often, because we are so precise in our kinetic deliveries. When we do kinetic, the precision with which we do that is so high that we do it, it doesn't take a second sortie, it doesn't take another mission. It gets done -- the ground commander's intent is met on the first try, and then we go back into an overwatch mode, and also primarily -- which is what we do so often -- is we go into an intelligence-gathering mode with surveillance of FOBs and COBs.

So I'd be glad to get you those numbers. And rather than give you a wag, I'd give you the exact numbers via an RFI, if you will.

Q: Thank you, General. Amy McCullough with Air Force Magazine. I was wondering if you could elaborate on the post-2014 footprint a little bit. I know you've talked about that quite a bit. But other than trainers, who -- who will we -- who will the air force still need in Afghanistan? And will there be a need to plus-up the footprint at the surrounding bases?

MAJ. GEN. POLUMBO: Amy, somehow we got a bad connection at that point. I think I -- I heard your name, but then if you could repeat the question, I'm sorry. I just didn't hear it.

Q: Sure, no problem. In addition to trainers, what other types of airmen do you see in Afghanistan post-2014? What type of career fields will be necessary? And do you see any need to kind of plus-up the footprint in surrounding gulf bases?

MAJ. GEN. POLUMBO: The types of airmen that we'll have besides the advise and assist airmen will be primarily airlift, people that assist in regards to any of the drawdown that might not yet be done and assisting with the aerial ports of demarcation for our retrograde ops, and then some manned ISR will be a small footprint, but, again, enough that it'll be a recognizable percentage of the footprint into '15.

And then what, you know, I'm so proud of as a U.S. air force, U.S. airman, is the fact that much of our remotely piloted aircraft that provide this long endurance, persistent watch of the target areas or of the friendly forces, is flown by reach back, it's flown by a distributed environment for our -- RPA pilots actually are back in Creech Air Force Base in Nevada or in Holloman in New Mexico, in other places.

So you can see the footprint goes way down, because of that ISR capability that will be so important into '15, but we'll do it with very few people forward. We'll launch and recover, as I would call it, pitch and catch the RPAs, and then most of the mission is flown reach back.

As far as your question on the rest of the gulf region, you know, it really is a CENTCOM discussion to have that. From my point of view, I wouldn't see any plus-ups significantly in anything we have in the over-the-horizon capability because we have such a sustained way of providing that capability with small footprint, what I call expeditionary airmen, that generally are not permanently assigned to these locations that come in, in our U.S. Air Force expeditionary rotation.

So I wouldn't expect it to plus-up in that regard, but, you know, CENTCOM probably has the better vantage point to answer that. But that's a good question, Amy, on both aspects.

CMDR. SPEAKS: Luis?

Q: General, it's Luis Martinez with ABC News. Just following up on Amy's question, which is exactly what I was going to ask, so you're saying that the enduring air component will not have combat air support capability beyond the over-the-horizon aircraft that may be needed? Is that correct?

And what -- what -- how long of a timeframe are we talking before the A-29, Super Tucano is operable by the Afghan air force?

MAJ. GEN. POLUMBO: Yeah, the A-29 will start coming into the inventory next year, not -- it will not be a factor -- yeah, okay. I'm sorry. There was a little bit of feedback. But, again, the Super Tucano A-29 is not anything in the '13 fighting cycle. It's next year where it starts to come onboard, and obviously most of that will have to be the initial training the cadre of Afghan air force pilots who will not only be prepared to fly it themselves, but also bring on and become the instructors in the airplane. So it'll be mid-'14 and into '15 where it starts to really reach some operational capability. So what does that mean for -- how does the air support be generated by anything still remaining in the coalition capabilities? We'll still have some fixed-wing capability to do air support, air- delivered munitions. It likely will include other nations besides the United States Air Force and the United States Navy and the United States Army. And I encourage that, for our NATO partners who have very robust capabilities over here right now in both rotary-wing and fixed-wing.

And likely, we would expect to see some of those nations stay into the resolute support mission in 2015 and beyond, all to be determined in the months to come as we go through the concept of operations that NATO will put in play and in negotiations with the nations, and ultimately into a final plan that will come to fruition in 2015.

I think the other piece that maybe you're asking about that I could help you with is, what other capabilities will have kinetic capabilities? And, again, I come back to the remotely piloted aircraft that not only the U.S. fly, but other nations fly -- the U.K. comes to mind -- that have hybrid ISR. They can collect intelligence, but they also are armed. And they're armed to be able to provide force protection to our coalition forces, and then our coalition ground force commanders, when they deem it appropriate, they can control that air delivered munition capability from the RPAs to be put in support of the Afghans.

So you'll have that hybrid ISR, as I call it, that armed ISR remotely piloted aircraft capability all the way through '14. And then once resolute support mission operations is fully understood and agreed upon by our coalition partners and our -- and our leadership, you likely will see it into 2015 to provide force protection.

Q: If I could follow up really quickly, are you -- are you talking about an integrated international aviation task force, I guess, where you would bring small numbers, each country would present small numbers of aircraft, fixed-wing aircraft that would all operate under the same umbrella?

MAJ. GEN. POLUMBO: I am. And it's what we have now. As you know, the coalition that we have of 50 willing nations -- most of them are NATO -- which makes it very straightforward for me as the senior NATO airman to operate. We know how we are integrated. We know how to talk to each other. We know how to pass taskings back and forth. We know how to do air space control measures, et cetera.

So we have that now, and I'm confident that that NATO coalition of the troop contributing nations that have air power, that it will likely be the same type of a set-up, albeit smaller, in the resolute support mission, so into 2015.

The interesting part of it is, we also have other non-NATO nations that have very significant air capabilities -- United Arab Emirates, UAE comes to mind -- and they -- after we work this into our existing NATO command-and-control structure, they are full participants and very, very capable of doing this day in and -- day in and day out. And into resolute support, you know, I would -- I would encourage and hope that the nations such as the UAE would also stay with us.

CMDR. SPEAKS: Okay, with that, sir, I will turn it over to you for any closing comments.

MAJ. GEN. POLUMBO: Well, I think you guys have been too easy on me, but it's been a pleasure to talk to you. There's an obvious understanding of the complexity of the environment by the questions that you all ask. They were really good questions. I appreciate it. Anything that I promised you a return on, we can through the ISAF structure that we have here, we can get that data to you.

I will close by saying it's an honor and a privilege as the senior U.S. and NATO airman to have served for the year and worked with so many great airmen and great soldiers and Marines and sailors and the civilians that are over here. And I have been flying in the Afghan airspace this year, as the commander, but also over the last three years, it's a very difficult place to fly. It's a very challenging environment to fly airplanes day and night, so I have nothing but the utmost admiration for our airmen and the maintenance personnel and the civilians that assist us in that regard, because it's so important.

The Afghan people deserve this try. General Dunford has defined how we should look at how to declare a win in this regard. And over the next 20 months, we have a lot of work to do to really, really assist the Afghans in a free and stable and vibrant and economically viable country.

So, again, thank you all for the opportunity to talk to you today, and we're out here from Kabul.

CMDR. SPEAKS: Thank you, sir.

ATTACKS REMEMBERED WITH U.S. NAVY PHOTOS



FROM: U.S. NAVY

010914-N-0000X-002 Pascagoula, Miss. (Sept. 14, 2001) – The Arleigh Burke-class destroyer USS Cole (DDG 67) is back in the water. Cole was relaunched at Northrop Grumman Ship Systems Ingalls Operations in Pascagoula, Miss., after repairs on her hull were completed. The ship was transported to Pascagoula following the October 12, 2000 terrorist attack in Yemen. U.S. Navy Photo (RELEASED)




010911-N-3783H-174 Arlington, Virginia (Sept. 11, 2001) -– Smoke and flames rose over the Pentagon late into the night, following a terrorist crash of a commercial airliner into the southwest corner of the Pentagon. Part of the building has collapsed meanwhile firefighters continue to battle the flames and look for survivors. The building was evacuated, as were the federal buildings in the Capitol area, including the White House. U.S. Navy Photo by Photographer’s Mate 2nd Class Bob Houlihan (Released)



BOSTON BOMBING SUSPECT CHARGED WITH USING A WMD

FROM: U.S. DEPARTMENT OF JUSTICE
Suspect in Boston Marathon Attack Charged with Using a Weapon of Mass Destruction

Attorney General Eric Holder announced today that Dzhokhar A. Tsarnaev, 19, a U.S. citizen and resident of Cambridge, Mass., has been charged with using a weapon of mass destruction against persons and property at the Boston Marathon on April 15, 2013, resulting in the death of three people and injuries to more than 200 people.

In a criminal complaint unsealed today in U.S. District Court for the District of Massachusetts, Tsarnaev is specifically charged with one count of using and conspiring to use a weapon of mass destruction (namely, an improvised explosive device or IED) against persons and property within the United States resulting in death, and one count of malicious destruction of property by means of an explosive device resulting in death. The statutory charges authorize a penalty, upon conviction, of death or imprisonment for life or any term of years. Tsarnaev had his initial court appearance today from his hospital room.

"Although our investigation is ongoing, today’s charges bring a successful end to a tragic week for the city of Boston, and for our country," said Attorney General Eric Holder. "Our thoughts and prayers remain with each of the bombing victims and brave law enforcement professionals who lost their lives or suffered serious injuries as a result of this week’s senseless violence. Thanks to the valor of state and local police, the dedication of federal law enforcement and intelligence officials, and the vigilance of members of the public, we’ve once again shown that those who target innocent Americans and attempt to terrorize our cities will not escape from justice. We will hold those who are responsible for these heinous acts accountable to the fullest extent of the law."

"The events of the past week underscore in stark terms the need for continued vigilance against terrorist threats both at home and abroad," said John Carlin, Acting Assistant Attorney General for National Security. "Friday’s arrest and today’s charges demonstrate what can be achieved by a collaborative, round-the clock response involving law enforcement officers, intelligence professionals, prosecutors and the general public."

"Today’s charges are the culmination of extraordinary law enforcement coordination and the tireless efforts of so many, including ordinary citizens who became heroes as they responded to the call for help in the hours and days following the Marathon tragedy," said Carmen Ortiz, U.S. Attorney for the District of Massachusetts. "The impact of these crimes has been far-reaching, affecting a worldwide community that is looking for peace and justice. We hope that this prosecution will bring some small measure of comfort both to the public at large and to the victims and their families that justice will be served. While we will not be able to comment on any possible communications between the suspect and law enforcement at this time, as a general rule, the government will always seek to elicit all the actionable intelligence and information we can from terrorist suspects taken into our custody."

"The events of this week have moved at a breakneck pace. Yet the one consistent element of this investigation has been the collective efforts of our law enforcement and intelligence partners, working side-by-side, day and night, to identify and find those responsible for this attack, while keeping the public safe," said Rick DesLauriers, Special Agent in Charge of the FBI’s Boston Division. "We are grateful to the American people for their assistance; we would not be successful without their trust and support. We will continue to investigate this matter with the greatest diligence and expediency, and we will do all that we can to protect those we serve."

"Friday night’s capture of the suspect brought immediate relief to a community from a public safety viewpoint. However, much work remains and many questions require answers. Today’s charges represent another step on the long road toward justice for the victims of these crimes. On behalf of the citizens of this great Commonwealth, the Massachusetts State Police will continue to work diligently with our federal and local partners to bring this defendant to justice for his alleged acts and ensure the public’s safety," said Colonel Timothy P. Alben, Superintendent of the Massachusetts State Police.

"Finding the alleged perpetrators of this savage act of terrorism four days after the attack on the City of Boston was a herculean effort and shows the true cooperation and dedication of the law enforcement community," said Boston Police Commissioner Ed Davis. "We were relentless in our pursuit of the suspects. The arrest of Tsarnaev and today’s charges should send a clear message to those who look to do us harm, the entire law enforcement community will go after you, find you and bring you to justice."

This investigation was conducted by the FBI’s Boston Division, the Boston Police Department, the Massachusetts State Police, and member agencies of the Boston Joint Terrorism Task Force, which is comprised of more than 30 federal, state and local enforcement agencies, including the Bureau of Alcohol, Tobacco, Firearms and Explosives, U.S. Immigration and Customs Enforcement – Homeland Security Investigations, U.S. Marshals Service, U.S. Secret Service, the Massachusetts Bay Transit Authority and others. In addition, the Watertown Police Department, the Cambridge Police Department, the Massachusetts Institute of Technology (MIT) Police Department, the Boston Fire Department, the National Guard and police, fire and emergency responders from across Massachusetts and New England played critical roles in the investigation and response.

This case is being prosecuted by Assistant U.S. Attorneys William Weinreb and Aloke Chakravarty from the Anti-Terrorism and National Security Unit of the U.S. Attorney’s Office for the District of Massachusetts, with assistance from the Counterterrorism Section of the Justice Department’s National Security Division.

The public is reminded that charges contained in an indictment or criminal complaint are merely allegations, and that defendants are presumed innocent unless and until proven guilty.

LOS ALAMOS NATIONAL LABORATORY WORKS TOWARD STEMMING THE ADVANCE OF TUBERCULOSIS


An anteroposterior X-ray of a patient diagnosed with advanced bilateral pulmonary tuberculosis  Credit:  CDC/Wikimedia.

FROM: LOS ALAMOS NATIONAL LABORATORY
Advancing the Art of Tuberculosis Detection
New approach to finding a TB biomarker could provide earlier diagnosis
LOS ALAMOS, N.M., April 19, 2013—New work from Los Alamos National Laboratory shows promise for stemming the advance of tuberculosis (TB) by revealing how the bacterium interacts with its human hosts and thus providing a new pathway for early detection in patients.

A recent publication from the Los Alamos Biosensor Team describes the association of a key tuberculosis virulence factor, lipoarabinomannan (LAM) with human high-density lipoproteins (HDL) in blood. "Understanding the pathophysiology of tuberculosis, and the distribution of pathogen-associated molecules in the host, is essential to developing efficient methods of intervention," said Harshini Mukundan, corresponding author on the paper.

"Association of lipoarabinomannan with high density lipoprotein in blood: Implications for diagnostics" Tuberculosis 93 (2013) was published April 3rd, 2013, in the journal Tuberculosis.

The team’s efforts have focused on using the LAM virulence factor as a sensitive indicator for TB. The problem has been that the biomarker, while being a reliable early indicator of TB, is very difficult to detect, especially in blood. Previously, the team has developed strategies for the detection of this biomarker in urine (Mukundan H et al, Tuberculosis, June 2012). Subsequently, they developed a strategy for the ultra-sensitive detection of the biomarker using a novel method, called membrane insertion (Mukundan H et al, Tuberculosis, Jan 2012)

The researchers extend the membrane insertion approach to the detection of molecules like LAM in patient serum using a device called an ultrasensitive wave-guide based biosensor. The measurement technique, or assay, exploits both the water-repellant and absorbent properties of LAM, a feature common to many bacterial virulence factors. These measurements raised a key question as to why the quantities of LAM in blood serum are usually low, despite high concentrations in urine from the same individuals.

It appears that LAM, an amphiphile (meaning it has both hydrophobic and hydrophilic components), is associated with carrier molecules such as HDL (a lipoprotein) in the blood of patients infected with tuberculosis. The concept is very simple. A drop of oil will not be free-floating in water. Similarly, amphiphilic LAM cannot be free floating in aqueous blood, but it associates with carrier molecules such as the lipoprotein HDL. Such an association is likely to affect host–pathogen interactions, pathogen distribution and clearance in the host, and must be thoroughly understood for the effective design of vaccines and diagnostics. The team has exploited this interaction to design a novel assay for the capture of such molecular components, termed HDL capture.

As it happens, many bacterial virulence factors share similar biochemical properties as LAM. Examples include the lipopolysaccharide from E. coli. Thus, this observation has far-reaching applications to the understanding of the interaction of the human host with many pathogens, not just TB.

Despite the global prevalence of the disease and its ancient association with the human population, current methods for the prevention, diagnosis and treatment of tuberculosis, especially its drug-resistant variants, remain inadequate. Through development of more sensitive detection techniques, earlier and more accurate diagnosis may become a simpler task.

Sponsorship and authors

The work was supported in part, by the Intramural Research Program of the National Institute of Allergy and Infectious Diseases, National Institutes of Health (CEB) and the South Korean Ministry of Health, Welfare and Family Affairs, World Health Organization FIND grant A50452; Special Program for Research and Training in Tropical Diseases, and a Los Alamos National Laboratory Directed Research Award.

Authors: Rama Murthy Sakamuri, Dominique N. Price, Basil I. Swanson, Harshini Mukundan (all of Los Alamos National Laboratory), Myungsun Lee, Sang Nae Cho (International Tuberculosis Research Center, Changwon, Republic of Korea), Clifton E. Barry 3rd, Laura E. Via (Tuberculosis Research Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD)

STATEMENTS BY DEFENSE SECRETARY HAGEL AND ISRAELI PRIME MINSTER NETANYAHU

U.S. Defense Secretary Chuck Hagel, left, and Israeli Prime Minister Benjamin Netanyahu speak to the press before meeting in Jerusalem, April 23, 2013. DOD photo by Erin A. Kirk-Cuomo
FROM: U.S. DEPARTMENT OF DEFENSE

Presenter: Secretary of Defense Chuck Hagel
April 23, 2013

Statements by Prime Minister Benjamin Netanyahu and US Secretary of Defense Chuck Hagel at their meeting at the Israeli Prime Minister's office, Jerusalem, Israel

PRIME MINISTER BENJAMIN NETANYAHU: Secretary Hagel, Chuck, welcome to Jerusalem again, but this time in your current capacity as secretary of defense.

This is a special welcome. In the last four years, we've greatly enhanced the defense and security relationship between Israel and the United States, and I am absolutely confident that we will continue to further strengthen this under your stewardship of the American defense establishment. This is important because we face many challenges, as you well know, and I look forward to discussing with you how we overcome these challenges in our continued cooperation.

Israel appreciates deeply, the support, the military and security support, that it enjoys from the United States – it reflects a very deep alliance between our two countries and the defense of our common interests and our common values.

Nowhere are these values and interests challenged more than by the arming of terrorist groups by Iran with sophisticated weapons, and equally, Iran's attempt to arm itself with nuclear weapons. This is a challenge that Israel cannot accept, and as you and President Obama have repeatedly said, Israel must be able to defend itself, by itself, against any threat. In any case, it is good to have you in Jerusalem. It is good to have the support, friendship and alliance of the United States. We deeply appreciate it. Welcome to Jerusalem.

SECRETARY CHUCK HAGEL: Thank you. Prime Minister Netanyahu, thank you. I am grateful for your personal courtesies, hospitality and personal relationship. I'm also pleased to be back in Israel. As you have noted, I have been here many times.

My first trip was in the late 1980's when I was president of the USO, and I've always appreciate this country, the people, the leadership and the courage that you represent and what has been produced in Israel. It is a model for the world, and the relationship between our two countries, just as you have noted, is as strong as it's ever been, not only measured by the military-to-military, all the other metrics that apply to relationships, but as you also noted, prime minister, it is based on common values and respect for others, and that is the foundation of any relationship.

You noted that the region is not getting any less complicated. This is a difficult and dangerous time. This is a time when friends and allies must remain close, closer than ever. I'm committed to continue to strengthen this relationship, secure this relationship, and as you know, one of the main reasons I'm here is to do that. I've had very good conversations the last two days with your defense minister. I had a good conversation with President Peres yesterday. I was able to take a long tour up in the north and the eastern borders here, and once again it reminds me of the dangers and difficulties and challenges.

But I believe together, working with our allies and our friends, we will be able to do what is right for your country, my country, and make this region a better region and a more secure region, and make Israel more secure. So I look forward to our conversation, and thank you for your many courtesies in welcoming me to Israel.

Thank you.

PRIME MINISTER NETANYAHU: Let's go work.

THE SHIPS COME IN, THE SHIPS GO OUT






FROM: U.S. NAVY

130419-N-DH124-045 SAN DIEGO (April 19, 2013) The Arleigh Burke-class guided-missile destroyer USS Decatur (DDG 73) returns to homeport San Diego, April 19, after completing an eight-month, ballistic missile defense deployment to the 5th and 7th Fleet areas of operation. While operating in the Arabian Gulf, the ship and her boarding team conducted 88 "approach-and-visit" operations that helped strengthen U.S. Navy ties with local mariners. (U.S. Navy photo by Mass Communication Specialist 2nd Class Rosalie Garcia/Released)




130419-N-DH124-125 SAN DIEGO (April 19, 2013)- The Arleigh Burke-class guided-missile destroyer USS Preble (DDG 88) departs homeport San Diego, April 19, for a six-month deployment to the 7th Fleet area of operations. While deployed, Preble is scheduled to participate in Cooperation and Readiness Afloat Training (CARAT) with partner nations in the region. (U.S. Navy photo by Mass Communication Specialist 2nd Class Rosalie Garcia/Released)

 

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