WEST NILE VIRUS AND TRANSFUSIONS

FROM:  CENTERS FOR DISEASE CONTROL AND PREVENTION 
Fatal West Nile Virus Infection Following Probable Transfusion-Associated Transmission—Colorado, 2012
CDC Media Relations
404-639-3286

Starting in 2003, the U.S. blood supply has been screened for West Nile virus.  Since then, approximately 3,500 West Nile virus-infected units have been removed from the blood supply and only 12 cases of transfusion-associated transmission of West Nile virus have been identified. This report describes the first probable case of transfusion-associated West Nile virus infection in which the donation was negative by individual nucleic acid testing on initial screening. The case occurred in an immunosuppressed patient who was likely more susceptible to infection at very low concentrations of West Nile virus in the transfused blood product. Transfusion-associated West Nile virus infections are rare.  However, healthcare providers should consider West Nile virus disease in any patient with compatible symptoms who has received a blood transfusion during the 28 days before the onset of illness.  Possible cases should be promptly reported to the blood collection agency and public health authorities

ANIMAL-TO-HUMAN INFECTIOUS DISEASE AT ANNUAL CONFERENCE

FROM:  CDC.  This is a male Ixodes ricinus tick (smaller) shown copulating with a female tick (larger). I. ricinus, the "castor bean" tick, so called because of its resemblance to the castor bean, is a vector for the B. burgdorferi spirochete, the cause of Lyme disease, and is commonly found on farm animals, and deer who are the natural host. Credit: Centers For Disease Control and Prevention/Wikimedia

FROM: THE NATONAL SCIENCE FOUNDATION

Interplay of Ecology, Infectious Disease, Wildlife and Human Health Featured at Annual Conference
West Nile virus, Lyme disease and hantavirus. All are infectious diseases spreading in animals and in people. Is human interaction with the environment somehow responsible for the increase in these diseases?

The ecology and evolution of infectious diseases will be highlighted at two symposia at the Ecological Society of America's annual meeting, held from Aug. 5-9 in Minneapolis, Minn.

One symposium will address human influences on viral and bacterial diseases through alteration of landscapes and ecological processes.

Another will focus on the emerging field of eco-epidemiology, which seeks to integrate biomedical and ecological research approaches to addressing human health threats.

Much of the research presented is funded by the joint National Science Foundation- (NSF) National Institutes of Health Ecology and Evolution of Infectious Diseases (EEID) Program.

"These sessions show that basic research is critical for managing disease threats," said Sam Scheiner, NSF EEID program director. "They also showcase the need to link scientists with public health professionals."

The first symposium, on Monday, Aug. 5, will take a deeper look at the connections between human activities and infectious diseases.

Though we often think of diseases as simply being "out there" in the environment, human actions--such as feeding birds--can influence the abundance, diversity and distribution of wildlife species and thus, infectious diseases.

"New human settlements, the spread of agriculture and the increasing proximity of people, their pets and livestock to wild animals increase the probability of disease outbreaks," said session organizer Courtney Coon of the University of South Florida.

"We're interested in learning more about how urban and other environments that humans dramatically change affect the susceptibility and transmission potential of animals that are hosts or vectors of disease."

What are the key determinants of spillover of wildlife diseases to domestic animals and humans?

Why is the prevalence of pathogens in wildlife in urban areas often altered by counterparts in less developed environments?

Speakers will address these and other questions.

The second symposium, on Tuesday, Aug. 6, will continue the theme of infectious diseases, but with an eye toward integrating biomedical and ecological approaches into the investigation and control of emerging diseases.

"Environmental processes and human health are linked, and we'd like to chart a future in which ecologists and epidemiologists more routinely work in tandem to address health problems," said symposium organizer Jory Brinkerhoff of the University of Richmond.

Scientists studying human diseases may overlook possible ecological factors.

For example, most Lyme disease cases in the eastern United States happen in the North even though the black-legged tick, which transmits the bacterium, is found throughout the Eastern states.

Human life histories and interactions with the environment, researchers say, are critically important to the success of managing a mosquito-borne virus called dengue fever.

"Disease ecologists and epidemiologists address some of the same kinds of questions, yet operate largely in isolation of one another," said Brinkerhoff.

"We're bringing them together to share their approaches and study designs, and to strengthen our ability to address public health issues."

Disease Ecology in Human-Altered Landscapes: Monday, Aug. 5, 2013, 1:30 p.m.-5 p.m., 205AB, Minneapolis Convention Center.
Organizer/Moderator: Courtney Coon, University of South Florida
Co-Organizer: James Adelman, Virginia Tech

Speakers:
Parviez Hosseini, EcoHealth Alliance
Matthew Ferrari, Penn State University
Marm Kilpatrick, University of California, Santa Cruz
Raina Plowright, Penn State University
Sonia Altizer, University of Georgia
Becki Lawson, Zoological Society of London
Eco-Epidemiology: A Multi-Disciplinary Approach to Addressing Public Health Problems: Tuesday, Aug. 6, 2013, 1:30 p.m.-5 p.m., 205AB Minneapolis Convention Center.
Organizer/Moderator: Jory Brinkerhoff, University of Richmond
Co-Organizer: Maria Diuk-Wasser, Yale School of Public Health

Speakers:
Maria Diuk-Wasser, Yale School of Public Health
Daniel Salkeld, Colorado State University
Mark Wilson, University of Michigan
James Holland Jones, Stanford University
Harish Padmanabha, National Center for Socio-Environmental Synthesis
Jean Tsao, Michigan State University
-NSF-

CDC FACTSHEET ON WEST NILE VIRUS

FROM: CENTERS FOR DISEASE CONTROL AND PREVENTION
West Nile Virus: What You Need To Know

CDC Fact Sheet
What Is West Nile Virus?
West Nile virus (WNV) is a potentially serious illness. Experts believe WNV is established as a seasonal epidemic in North America that flares up in the summer and continues into the fall. This fact sheet contains important information that can help you recognize and prevent West Nile virus.

What Can I Do to Prevent WNV?

Prevention measures consist of community-based mosquito control programs that are able to reduce vector populations, personal protection measures to reduce the likelihood of being bitten by infected mosquitoes, and the underlying surveillance programs that characterize spatial/temporal patterns in risk that allow health and vector control agencies to target their interventions and resources.

The easiest and best way to avoid WNV is to prevent mosquito bites.
When you are outdoors, use insect repellent containing an EPA-registered active ingredient. Follow the directions on the package.
Many mosquitoes are most active at dusk and dawn. Be sure to use insect repellent and wear long sleeves and pants at these times or consider staying indoors during these hours.
Make sure you have good screens on your windows and doors to keep mosquitoes out.
Get rid of mosquito breeding sites by emptying standing water from flower pots, buckets and barrels. Change the water in pet dishes and replace the water in bird baths weekly. Drill holes in tire swings so water drains out. Keep children's wading pools empty and on their sides when they aren't being used.
What Are the Symptoms of WNV?
Serious Symptoms in a Few People. About one in 150 people infected with WNV will develop severe illness. The severe symptoms can include high fever, headache, neck stiffness, stupor, disorientation, coma, tremors, convulsions, muscle weakness, vision loss, numbness and paralysis. These symptoms may last several weeks, and neurological effects may be permanent.
Milder Symptoms in Some People. Up to 20 percent of the people who become infected have symptoms such as fever, headache, and body aches, nausea, vomiting, and sometimes swollen lymph glands or a skin rash on the chest, stomach and back. Symptoms can last for as short as a few days, though even healthy people have become sick for several weeks.
No Symptoms in Most People. Approximately 80 percent of people (about 4 out of 5) who are infected with WNV will not show any symptoms at all.
How Does West Nile Virus Spread?
Infected Mosquitoes. Most often, WNV is spread by the bite of an infected mosquito. Mosquitoes become infected when they feed on infected birds. Infected mosquitoes can then spread WNV to humans and other animals when they bite.
Transfusions, Transplants, and Mother-to-Child. In a very small number of cases, WNV also has been spread through blood transfusions, organ transplants, breastfeeding and even during pregnancy from mother to baby.
Not through touching. WNV is not spread through casual contact such as touching or kissing a person with the virus.
How Soon Do Infected People Get Sick?

People typically develop symptoms between 3 and 14 days after they are bitten by the infected mosquito.

How Is WNV Infection Treated?

There is no specific treatment for WNV infection. In cases with milder symptoms, people experience symptoms such as fever and aches that pass on their own, although even healthy people have become sick for several weeks. In more severe cases, people usually need to go to the hospital where they can receive supportive treatment including intravenous fluids, help with breathing and nursing care.

What Should I Do if I Think I Have WNV?

Milder WNV illness improves on its own, and people do not necessarily need to seek medical attention for this infection though they may choose to do so. If you develop symptoms of severe WNV illness, such as unusually severe headaches or confusion, seek medical attention immediately. Severe WNV illness usually requires hospitalization. Pregnant women and nursing mothers are encouraged to talk to their doctor if they develop symptoms that could be WNV.

WEST NILE VIRUS STRIKES EARLY THIS YEAR

050910-N-2653P-132 Naval Air Station (NAS) Joint Reserve Base (JRB) New Orleans, La. (Sept. 10, 2005) - Preventative Medicine Technician (PMT), Hospital Corpsman 1st Class Jonathan Wells, assigned to Forward Deployable Preventive Medicine Unit (FDPMU) East, removes a Light Trap provided by the Centers for Disease Control (CDC) from a tent city area on board NAS JRB New Orleans. The FDPMU is assisting the CDC and the Louisiana Department of Public Health to eliminate vector-borne disease and other insect-related problems associated with Louisiana’s mosquito population. Diseases like West Nile Virus can be transmitted by mosquitoes, which thrive in wet ecological terrain like that inherent to Louisiana. U.S. Navy photo by Journalist 1st Class James Pinsky (RLEASED)

FROM: CENTERS FOR DISEASE CONTROL
The Centers for Disease Control and Prevention is urging people to take steps to prevent West Nile virus infections. Outbreaks of West Nile virus disease occur each summer in the United States. This year, some areas of the country are experiencing earlier and greater activity.

Thus far in 2012, 42 states have reported West Nile virus infections in people, birds, or mosquitoes. A total of 241 cases of West Nile virus disease, including four deaths, have been reported to CDC. This is the highest number of cases reported through the end of July since 2004. Almost 80 percent of the cases have been reported from three states, Texas, Mississippi, and Oklahoma.

West Nile virus is transmitted to people by infected mosquitoes. In the United States, most people are infected from June through September, and the number of these infections usually peaks in mid-August. Seasonal outbreaks often occur in local areas that can vary from year to year. Many factors impact when and where outbreaks occur, such as weather, numbers of mosquitoes that spread the virus, and human behavior.

"It is not clear why we are seeing more activity than in recent years," said Marc Fischer, M.D., M.P.H., medical epidemiologist with CDC’s Arboviral Diseases Branch. "Regardless of the reasons for the increase, people should be aware of the West Nile virus activity in their area and take action to protect themselves and their family."

The best way to prevent West Nile virus disease is to avoid mosquito bites:
Use insect repellents when you go outdoors.
Wear long sleeves and pants during dawn and dusk.
Install or repair screens on windows and doors. Use air conditioning, if you have it.
Empty standing water from items outside your home such as flowerpots, buckets, and kiddie pools.
Approximately 1 in 5 people who are infected with West Nile virus will develop symptoms such as fever, headache, body aches, joint pains, vomiting, diarrhea, or rash. Less than 1 percent will develop a serious neurologic illness such as encephalitis or meningitis (inflammation of the brain or surrounding tissues). About 10 percent of people who develop neurologic infection due to West Nile virus will die. People over 50 years of age and those with certain medical conditions, such as cancer, diabetes, hypertension, kidney disease, and organ transplants, are at greater risk for serious illness.

There are no medications to treat, or vaccines to prevent, West Nile virus infection. People with milder illnesses typically recover on their own, although symptoms may last for several weeks. In more severe cases, patients often need to be hospitalized to receive supportive treatment, such as intravenous fluids, pain medication, and nursing care. Anyone who has symptoms that cause concern should contact a health care provider.