OSHA CITES UNIVERSITY FOR EXPOSING FACULTY TO FORMALDEHYDE

FROM:  U.S. LABOR DEPARTMENT
OSHA cites Nova Southeastern University for exposing faculty to high levels of formaldehyde
Employer name: Nova Southeastern University

Inspection site: 3301 College Ave., Fort Lauderdale, Florida 33314
Date inspection initiated: The U.S. Department of Labor's Occupational Safety and Health Administration initiated the investigation on Nov. 5, 2014, after receiving a complaint about faculty in the anatomy lab being exposed to formaldehyde.

Inspection findings:

OSHA issued 10 serious citations to the employer for not providing personal protective equipment to workers exposed to formaldehyde; exposing workers to formaldehyde levels beyond the safe exposure limits; not providing a medical surveillance program for workers found to be over the short term exposure limit; not taking corrective action to reduce worker exposure; and not providing eyewash stations in the work area where workers prepared a formaldehyde solution. Additionally, the employer failed to provide the employees who were over the exposure limit their sampling results and neglected to take the necessary steps to reduce or eliminate the exposure. A serious violation occurs when there is substantial probability that death or serious physical harm could result from a hazard about which the employer knew or should have known.

Quote: "Nova Southeastern University failed to protect its workers from the hazards of over-exposure to formaldehyde," said Beatriz Cabrera acting area director of OSHA's Fort Lauderdale Area Office. "Formaldehyde can irritate the eyes and nose, and cause coughing and wheezing. It is a sensitizer, which means that it can cause allergic reactions of the lungs, skin and eyes, such as asthma, rashes and itching. It also has been linked to cancer."

Proposed Penalties: $50,000

EPA TAKES ACTION PROTECTING PUBLIC FROM CERTAIN CHEMICALS

FROM:  U.S. ENVIRONMENTAL PROTECTION AGENCY 
FOR IMMEDIATE RELEASE
December 17, 2014

WASHINGTON – The U.S. Environmental Protection Agency (EPA) is taking action to protect the public from certain chemicals that have the potential to cause a range of health effects from cancer to reproductive and developmental harm to people and aquatic organisms.

“We are committed to protecting all Americans from exposure to harmful chemicals used in domestic and imported products,” said Jim Jones, assistant administrator for chemical safety and pollution prevention. “There must be a level playing field for U.S. businesses – which is why we’re targeting harmful chemicals no longer used in the U.S. that find their way into commerce, sometimes through imported products. This final action will give EPA the opportunity to restrict or limit any new uses of these chemicals, including imported goods with these chemicals.”
Today’s action addresses the following chemicals:

Most uses of certain benzidine-based dyes which can be used in textiles, paints and inks and can be converted in the body into a chemical that is known to cause cancer;

Most uses of DnPP, a phthalate, which can be used in PVC plastics and has been shown to cause developmental and/or reproductive effects in laboratory animals; and

Alkanes C 12-13, chloro, a short-chain chlorinated paraffin (SCCP), which can be used as industrial lubricants and are persistent, bioaccumulative and toxic to aquatic organisms at low concentrations and can be transported globally in the environment.

Some of the chemicals in today’s rule have previously been used in consumer products but are not used in the market today. Today’s Significant New Use Rules (SNURs) issued under the Toxic Substances Control Act allow EPA to review any efforts by manufacturers, including importers, to introduce these chemicals into the market and take appropriate action to ensure that human health and the environment are protected. EPA believes that new uses of these chemicals should not be allowed without an opportunity for review and, if necessary, to place restrictions on these chemicals, as warranted.
The action adds nine benzidine-based dyes to an existing SNUR. It closes a loophole to ensure that these chemicals and products containing them, such as clothing, cannot be imported without EPA review and possible restriction. EPA has investigated safer dyes and colorants as alternatives to benzidine as part of its Safer Chemical Ingredients List and Design for the Environment program.

In 2012, EPA required companies to stop manufacturing and importing SCCPs and to pay fines as a result of an enforcement action.

EPA is further evaluating related medium-chain (MCCPs) and long-chain chlorinated paraffins (LCCPs) as part of the TSCA Work Plan for Chemical Assessments.

EPA has added several phthalates to the TSCA Work Plan for Chemical Assessments. If a TSCA Work Plan assessment indicates a potential risk, the agency would determine if risk reduction actions, as appropriate, should be taken.

These final SNURs will require anyone who wishes to manufacture (including import) or process these chemical substances for a significant new use to notify EPA 90 days before starting or resuming new uses of these chemicals. This notice will provide EPA with the opportunity to evaluate the intended use of the chemicals and, if necessary, take action to prohibit or limit the activity.

CDC REPORTS THAT DISABLED HAVE LESS ACTIVITY AND MORE CHRONIC DISEASE

FROM:  CENTERS FOR DISEASE CONTROL AND PREVENTION 

Inactivity Related to Chronic Disease in Adults with Disabilities
Half of adults with disability get no aerobic physical activity
Working age adults with disabilities who do not get any aerobic physical activity are 50 percent more likely than their active peers to have a chronic disease such as cancer, diabetes, stroke, or heart disease, according to a Vital Signs report released today by the Centers for Disease Control and Prevention (CDC).
Nearly half (47 percent) of adults with disabilities who are able to do aerobic physical activity do not get any. An additional 22 percent are not active enough. Yet only about 44 percent of adults with disabilities who saw a doctor in the past year got a recommendation for physical activity.

“Physical activity is the closest thing we have to a wonder drug,” said CDC Director Tom Frieden, M.D., M.P.H. “Unfortunately, many adults with disabilities don’t get regular physical activity.  That can change if doctors and other health care providers take a more active role helping their patients with disabilities develop a physical fitness plan that’s right for them.”

Most adults with disabilities are able to participate in some aerobic physical activity which has benefits for everyone by reducing the risk of serious chronic diseases. Some of the benefits from regular aerobic physical activity include increased heart and lung function; better performance in daily living activities; greater independence; decreased chances of developing chronic diseases; and improved mental health.

For this report, CDC analyzed data from the 2009-2012 National Health Interview Survey and focused on the relation between physical activity levels and chronic diseases among U.S. adults aged 18-64 years with disabilities, by disability status and type.  These are adults with serious difficulty walking or climbing stairs; hearing; seeing; or concentrating, remembering, or making decisions. Based on the 2010 data, the study also assessed the prevalence of receiving a health professional recommendation for physical activity and the association with the level of aerobic physical activity.

Key findings include:

Working age adults with disabilities are three times more likely to have heart disease, stroke, diabetes or cancer than adults without disabilities.
Nearly half of adults with disabilities get no aerobic physical activity, an important protective health behavior to help avoid these chronic diseases.
Inactive adults with disabilities were 50 percent more likely to report at least one chronic disease than were active adults with disabilities.
Adults with disabilities were 82 percent more likely to be physically active if their doctor recommended it.

The Physical Activity Guidelines for Americans recommend that all adults, including those with disabilities, get at least 150 minutes (2.5 hours) of moderate – intensity aerobic physical activity each week. If meeting these guidelines is not possible, adults with disabilities should start physical activity slowly based on their abilities and fitness level.

Doctors and other health professionals can recommend physical activity options that match the abilities of adults with disabilities and resources that can help overcome barriers to physical activity. These barriers include limited information about accessible facilities and programs; physical barriers in the built or natural environment; physical or emotional barriers to participating in fitness and recreation activities, and lack of training in accessibility and communication among fitness and recreation professionals.

“It is essential that we bring together adults with disabilities, health professionals and community leaders to address resource needs to increase physical activity for people with disabilities,” said Coleen Boyle, Ph.D., M.S. hyg., director of CDC’s National Center on Birth Defects and Developmental Disabilities.

CDC has set up a dedicated resource page for doctors and other health professionals with information to help them recommend physical activity to their adult patients with disabilities, www.cdc.gov/disabilities/PA.  

Through the Affordable Care Act, more Americans have access to health coverage and to no-cost preventive services. Most health insurance plans cannot deny, limit, or exclude coverage to anyone based on a pre-existing condition, including persons with disabilities. To learn more about the Affordable Care Act, visit Healthcare.gov or call 1-800-318-2596 (TTY/TDD 1-855-889-4325).

Vital Signs is a CDC report that appears on the first Tuesday of the month as part of the CDC journal Morbidity and Mortality Weekly Report, or MMWR. The report provides the latest data and information on key health indicators. These are cancer prevention, obesity, tobacco use, motor vehicle passenger safety, prescription drug overdose, HIV/AIDS, alcohol use, health care-associated infections, cardiovascular health, teen pregnancy, food safety and developmental disabilities.

CDC SAYS UP TO 40 PERCENT OF DEATHS FROM 5 LEADING CAUSES ARE PREVENTABLE

FROM:  CENTERS OF DISEASE CONTROL AND PREVENTION 

Up to 40 percent of annual deaths from each of five leading US causes are preventable

Each year, nearly 900,000 Americans die prematurely from the five leading causes of death – yet 20 percent to 40 percent of the deaths from each cause could be prevented, according to a study from the Centers for Disease Control and Prevention.

The five leading causes of death in the United States are heart disease, cancer, chronic lower respiratory diseases, stroke, and unintentional injuries. Together they accounted for 63 percent of all U.S. deaths in 2010, with rates for each cause varying greatly from state to state.  The report, in this week’s issue of CDC’s weekly journal, Morbidity and Mortality Weekly Report, analyzed premature deaths (before age 80) from each cause for each state from 2008 to 2010. The authors then calculated the number of deaths from each cause that would have been prevented if all states had same death rate as the states with the lowest rates.
The study suggests that, if all states had the lowest death rate observed for each cause, it would be possible to prevent:

34 percent of premature deaths from heart diseases, prolonging about 92,000 lives
21 percent of premature cancer deaths, prolonging about 84,500 lives

39 percent of premature deaths from chronic lower respiratory diseases, prolonging about 29,000 lives

33 percent of premature stroke deaths, prolonging about 17,000 lives

39 percent of premature deaths from unintentional injuries, prolonging about 37,000 lives

“As a doctor, it is heartbreaking to lose just one patient to a preventable disease or injury – and it is that much more poignant as the director of the nation’s public health agency to know that far more than a hundred thousand deaths each year are preventable,” said Tom Frieden, MD, MPH. “With programs such as the CDC’s Million Hearts initiative, we are working hard to prevent many of these premature deaths.”

The numbers of preventable deaths from each cause cannot be added together to get an overall total, the authors note. That’s because prevention of some premature deaths may push people to different causes of death. For example, a person who avoids early death from heart disease still may die prematurely from another preventable cause, such as an unintentional injury.
Modifiable risk factors are largely responsible for each of the leading causes of death:
Heart disease risks include tobacco use, high blood pressure, high cholesterol, type 2 diabetes, poor diet, overweight, and lack of physical activity.

Cancer risks include tobacco use, poor diet, lack of physical activity, overweight, sun exposure, certain hormones, alcohol, some viruses and bacteria, ionizing radiation, and certain chemicals and other substances.

Chronic respiratory disease risks include tobacco smoke, second-hand smoke exposure, other indoor air pollutants, outdoor air pollutants, allergens, and exposure to occupational agents.

Stroke risks include high blood pressure, high cholesterol, heart disease, diabetes, overweight, previous stroke, tobacco use, alcohol use, and lack of physical activity.

Unintentional injury risks include lack of seatbelt use, lack of motorcycle helmet use, unsafe consumer products, drug and alcohol use (including prescription drug misuse), exposure to occupational hazards, and unsafe home and community environments.

Many of these risks are avoidable by making changes in personal behaviors. Others are due to disparities due to the social, demographic, environmental, economic, and geographic attributes of the neighborhoods in which people live and work. The study authors note that if health disparities were eliminated, as called for in Healthy People 2020External Web Site Icon, all states would be closer to achieving the lowest possible death rates for the leading causes of death.
”We think that this report can help states set goals for preventing premature death from the conditions that account for the majority of deaths in the United States,” said Harold W. Jaffe, MD, the study’s senior author and CDC’s associate director for science. “Achieving these goals could prolong the lives of tens of thousands of Americans.”

Southeastern states had the highest number of preventable deaths for each of the five causes. The study authors suggest that states with higher rates can look to states with similar populations, but better outcomes, to see what they are doing differently to address leading causes of death.

CYRAMZA APPROVED BY FDA FOR TREATMENT OF STOMACH CANCER

FROM:  U.S. FOOD AND DRUG ADMINISTRATION 

For Immediate Release: April 21, 2014

Consumer Inquiries: 888-INFO-FDA

FDA approves Cyramza for stomach cancer

The U.S. Food and Drug Administration today approved Cyramza (ramucirumab) to treat patients with advanced stomach cancer or gastroesophageal junction adenocarcinoma, a form of cancer located in the region where the esophagus joins the stomach.

Stomach cancer forms in the tissues lining the stomach and mostly affects older adults. According to the National Cancer Institute, an estimated 22,220 Americans will be diagnosed with stomach cancer and 10,990 will die from the disease, this year.

Cyramza is an angiogenesis inhibitor that blocks the blood supply to tumors. It is intended for patients whose cancer cannot be surgically removed (unresectable) or has spread (metastatic) after being treated with a fluoropyrimidine- or platinum-containing therapy.

“Although the rates of stomach cancer in the United States have decreased over the past 40 years, patients require new treatment options, particularly when they no longer respond to other therapies,” said Richard Pazdur, M.D., director of the Office of Hematology and Oncology Products in the FDA’s Center for Drug Evaluation and Research. “Cyramza is new treatment option that has demonstrated an ability to extend patients’ lives and slow tumor growth.”

Cyramza’s safety and effectiveness were evaluated in a clinical trial of 355 participants with unresectable or metastatic stomach or gastroesophageal junction cancer. Two-thirds of trial participants received Cyramza while the remaining participants received a placebo. The trial was designed to measure the length of time participants lived before death (overall survival).

Results showed participants treated with Cyramza experienced a median overall survival of 5.2 months compared to 3.8 months in participants receiving placebo. Additionally, participants who took Cyramza experienced a delay in tumor growth (progression-free survival) compared to participants who were given placebo. Results from a second clinical trial that evaluated the efficacy of Cyramza plus paclitaxel (another cancer drug) versus paclitaxel alone also showed an improvement in overall survival.

Common side effects experienced by Cyramza-treated participants during clinical testing include diarrhea and high blood pressure.

The FDA reviewed Cyramza under its priority review program, which provides an expedited review for drugs that have the potential, at the time the application was submitted, to be a significant improvement in safety or effectiveness in the treatment of a serious condition. Cyramza was also granted orphan product designation because it is intended to treat a rare disease or condition.

Cyramza is marketed by Indianapolis-based Eli Lilly.

For more information:

FDA: Office of Hematology and Oncology Products

FDA: Approved Drugs: Questions and Answers

FDA: Drug Innovation

NCI: Stomach Cancer

The FDA, an agency within the U.S. Department of Health and Human Services, protects the public health by assuring the safety, effectiveness, and security of human and veterinary drugs, vaccines and other biological products for human use, and medical devices. The agency also is responsible for the safety and security of our nation’s food supply, cosmetics, dietary supplements, products that give off electronic radiation, and for regulating tobacco products.

FDA TELLS PEOPLE TO CUT DOWN ON ACRYLAMIDE', OFFERS WAYS TO CUT BACK ON CONSUMPTION

FROM:  U.S. FOOD AND DRUG ADMINISTRATION 
You Can Help Cut Acrylamide in Your Diet

If you're trying to lose weight, you may already be telling your waiter to hold the fries. Now there's another health benefit you can reap: Cutting down on certain fried foods can also help you cut down on the amount of acrylamide you eat. That's a good thing because high levels of acrylamide have been found to cause cancer in animals, and on that basis scientists believe it is likely to cause cancer in humans as well.

FDA chemist Lauren Robin explains that acrylamide is a chemical that can form in some foods—mainly plant-based foods—during high-temperature cooking processes like frying and baking. These include potatoes, cereals, coffee, crackers or breads, dried fruits and many other foods. According to the Grocery Manufacturers Association, acrylamide is found in 40 percent of the calories consumed in the average American diet.

While acrylamide has probably been around as long as people have been baking, roasting, toasting or frying foods, it was only in 2002 that scientists first discovered the chemical in food. Since then, the FDA has been actively investigating the effects of acrylamide as well as potential measures to reduce it. Today, the FDA posts a draft document with practical strategies to help growers, manufacturers and food service operators lower the amount of acrylamide in foods associated with higher levels of the chemical.

In addition, there are a number of steps you and your family can take to cut down on the amount of acrylamide in the foods you eat.

Acrylamide forms from sugars and an amino acid that are naturally present in food. It does not form, or forms at lower levels, in dairy, meat and fish products. The formation occurs when foods are cooked at home and in restaurants as well as when they are made commercially.

"Generally speaking, acrylamide is more likely to accumulate when cooking is done for longer periods or at higher temperatures," Robin says. Boiling and steaming foods do not typically form acrylamide.
Tips for Cutting Down on Acrylamide
Given the widespread presence of acrylamide in foods, it isn't feasible to completely eliminate acrylamide from one's diet, Robin says. Nor is it necessary. Removing any one or two foods from your diet would not have a significant effect on overall exposure to acrylamide.

However, here are some steps you can take to help decrease the amount of acrylamide that you and your family consume:

Frying causes acrylamide formation. If frying frozen fries, follow manufacturers' recommendations on time and temperature and avoid overcooking, heavy crisping or burning.
Toast bread to a light brown color rather than a dark brown color. Avoid very brown areas.
Cook cut potato products such as frozen french fries to a golden yellow color rather than a brown color. Brown areas tend to contain more acrylamide.
Do not store potatoes in the refrigerator, which can increase acrylamide during cooking. Keep potatoes outside the refrigerator in a dark, cool place, such as a closet or a pantry.
FDA also recommends that you adopt a healthy eating plan, consistent with the Dietary Guidelines for Americans, including:

Eat plenty of fruits, vegetables, whole grains, and fat-free or low-fat milk products.
Include lean meats, poultry, fish, beans, eggs and nuts.
Choose foods low in saturated fats, trans fat (which both raises your bad LDL cholesterol and lowers your good HDL cholesterol and is linked to heart attacks), cholesterol, salt and added sugars.
This article appears on FDA's Consumer Updates page, which features the latest on all FDA-regulated products.

November 14, 2013

TEENS AND SMOKELESS TOBACCO

FROM:  DEPARTMENT OF HEALTH AND HUMAN SERVICES

From the U.S. Department of Health and Human Services, I’m Ira Dreyfuss with HHS HealthBeat.

It’s bad for a teen to smoke, but smokeless is no good, either. Smokeless tobacco – things like dip, snuff and dissolvable – are also cancer-causers. And a study indicates about 1 in 20 middle school or high school students use smokeless. Researchers at the Harvard School of Public Health saw that in national survey data.

The scientists also saw the power of peer pressure. Researcher Constantine Vardavas:

“Adolescents who had a friend that used smokeless tobacco were 10 times more likely to use smokeless tobacco themselves.”

For comparison, teens with a family member who used smokeless were only 3 times more likely to use it.

Nearly all of the smokeless users reported it’s easy to get the stuff.

The study in the journal Pediatrics was supported by the National Institutes of Health.

Learn more at healthfinder.gov.

HHS HealthBeat is a production of the U.S. Department of Health and Human Services. I’m Ira Dreyfuss.

Last revised: August 19, 2013

HHS ARTICLE ON VACCINATION AGAINST HUMAN PAPILLOMAVIRUS

FROM:   U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES

From the U.S. Department of Health and Human Services, I’m Ira Dreyfuss with HHS HealthBeat.

Infection with the human papillomavirus, or HPV, can lead to cancers of the cervix and throat, as well as other body parts. However, a vaccine protects against forms of HPV that most frequently cause cancer.  At the Centers for Disease Control and Prevention, researcher Shannon Stokley:

“The HPV vaccine series consists of three doses, and it’s recommended that all girls and boys receive this vaccine at age 11 or 12.”

Stokley adds that it’s not too late to get vaccinated even up to age 26.  But the vaccine has been out since 2006, and she says coverage is still very low – partly because people don’t know about it and its benefits.

BACTERIAL DNA HUMAN GENOME INTEGRATION AND TUMOR TISSUE

Image: DNA Credit: NCI/Wikimedia

FROM: NATIONAL SCIENCE FOUNDATION

Bacterial DNA May Integrate Into Human Genome More Readily in Tumor Tissue
Bacterial DNA may integrate into the human genome more readily in tumors than in normal human tissue, scientists have found.


The researchers, affiliated with the University of Maryland School of Medicine's Institute for Genome Sciences, analyzed genomic sequencing data available from the Human Genome Project, the 1,000 Genomes Project and The Cancer Genome Atlas.

They considered the phenomenon of lateral gene transfer (LGT), the transmission of genetic material between organisms in a manner other than than traditional reproduction.

Scientists have already shown that bacteria can transfer DNA to the genome of an animal.

The researchers found evidence that lateral gene transfer is possible from bacteria to the cells of the human body, known as human somatic cells.

They found that bacterial DNA was more likely to integrate in the genome in tumor samples than in normal, healthy somatic cells. The phenomenon might play a role in cancer and other diseases associated with DNA damage.

"Advances in genomic and computational sciences are revealing the vast ways in which humans interact with an ever-present and endlessly diverse planet of microbes," says Matt Kane, program director in the National Science Foundation's Division of Environmental Biology in its Directorate for Biological Sciences, which funded the research.

"This discovery underscores the benefits that can result from a shift in our understanding of how this vast diversity of microbes and their genes may affect our health."

The results may lead to advances in personalized medicine, scientists say, in which doctors use each patient's genomic make-up to determine care and preventive measures.

A paper reporting the results is published today in the journal PLOS Computational Biology.

"LGT from bacteria to animals was only described recently, and it is exciting to find that such transfers can be found in the genome of human somatic cells and particularly in cancer genomes," says Julie Dunning Hotopp of the University of Maryland School of Medicine and lead author of the paper.

Hotopp also is a research scientist at the University of Maryland Marlene and Stewart Greenebaum Cancer Center.

"Studies applying this approach to additional cancer genome projects could be fruitful, leading us to a better understanding of the mechanisms of cancer."

The researchers found that while only 63.5 percent of TCGA samples analyzed were from tumors, the tumor samples contained 99.9 percent of reads supporting bacterial integration.

The data present a compelling case that LGT occurs in the human somatic genome, and that it could have an important role in cancer and other human diseases associated with mutations.

It's possible that LGT mutations play a role in carcinogenesis, the scientists say, yet it's also possible that they could simply be "passenger mutations."

The investigators suggest several competing ideas to explain the results, though more research is needed for definitive answers.

One possibility is that the mutations are part of carcinogenesis, the process by which normal cells turn into cancer cells.

Alternatively, tumor cells are very rapidly proliferating, so much so that they may be more permissive to lateral gene transfer.

It's also possible that bacteria are causing these mutations because they benefit the bacteria themselves.

The study was also funded by the National Institutes of Health.

-NSF-
Media Contacts
Cheryl Dybas, NSF cdybas@nsf.gov

EPA ANNOUNCES PROPOSAL TO REDUCE TOXIC DISCHARGES INTO WATERWAYS BY POWER PLANTS

Lake Superior.  Credit:  Wikimedia.

FROM: U.S. ENVIRONMENTAL PROTECTION AGENCY

EPA Proposes to Reduce Toxic Pollutants Discharged into Waterways by Power Plants

WASHINGTON — In accordance with a consent decree and in line with requirements under the Clean Water Act, the U.S. Environmental Protection Agency (EPA) today will propose a range of options to help reduce dangerous pollutants, including mercury, arsenic, lead, and selenium that are released into America’s waterways by coal ash, air pollution control waste and other waste from steam electric power plants. Today’s proposal includes a variety of options for whether and how these different waste streams should be treated. EPA will take comment on all of these options, which it will use to help inform the most appropriate final standard.

Steam electric power plants currently account for more than half of all toxic pollutants discharged into streams, rivers and lakes from permitted industrial facilities in the United States. High exposure to these types of pollutants has been linked to neurological damage and cancer as well as damage to the circulatory system, kidneys and liver.Toxic heavy metals do not break down in the environment and can also contaminate sediment in waterways and impact aquatic life and wildlife, including large-scale die-offs of fish.

"America’s waterways are vital to the health and well-being of our communities," said Acting Administrator Bob Perciasepe. "Reducing the pollution of our waters through effective but flexible controls such as we are proposing today is a win-win for our public health and our economic vitality. We look forward to hearing from all stakeholders on the best way forward."

EPA has put a focus on ensuring any final rule would protect public health while being sensible and achievable, and in line with that goal, under every preferred option proposed by EPA today, more than half of America’s coal fired power plants would be in compliance without incurring any additional cost.

The proposal updates standards that have been in place since 1982, incorporating technology improvements in the steam electric power industry over the last three decades as required by the Clean Water Act. The proposed national standards are based on data collected from industry and provide flexibility in implementation through a phased-in approach and use of technologies already installed at a number of plants. Under the proposed approach, new requirements for existing power plants would be phased in between 2017 and 2022, and would leverage flexibilities as necessary.

Fewer than half of coal-fired power plants are estimated to incur costs under any of the proposed preferred options, because many power plants already have the technology and procedures in place to meet the proposed pollution control standards.

The four preferred options differ in the number of waste streams covered (such as fly ash handling systems, treatment of air pollution control waste and bottom ash), the size of the units controlled and the stringency of the treatment controls to be imposed. EPA estimates that the regulations would reduce pollutant discharges by 470 million to 2.62 billion pounds annually and reduce water use by 50 billion to 103 billion gallons per year.

EPA also announced its intention to align this Clean Water Act rule with a related rule for coal combustion residuals (CCRs, also known as "coal ash") proposed in 2010 under the Resource Conservation and Recovery Act. The two rules would apply to many of the same facilities and would work together to reduce pollution associated with coal ash and related wastes. EPA is seeking comment from industry and other stakeholders to ensure that both final rules are aligned to reduce pollution efficiently and minimize regulatory burdens.

There are approximately 1,200 steam electric power plants that generate electricity using nuclear fuel or fossil fuels such as coal, oil, and natural gas in the U.S. Approximately 500 of these power plants are coal fired units which are the primary source of the pollutants being addressed by the proposed regulation. Power plants that are smaller than 50 megawatts would not be impacted by these new standards, and the majority of coal-fired power plants would incur no costs under the proposed standards.

The public comment period on the proposed rule will be open for 60 days after publication in the Federal Register. The agency is under a consent decree to take final action by May 22, 2014.

LASER RESEARCH MAY YIELD CANCER TREATMENT

FROM: LOS ALAMOS NATIONAL LABORATORY

Laser Research Shows Promise for Cancer Treatment
New insights gained on how lasers generate ions in dense plasmas

　
LOS ALAMOS, NEW MEXICO, August 20, 2012—Scientists at Los Alamos National Laboratory have observed for the first time how a laser penetrates dense, electron-rich plasma to generate ions. The process has applications for developing next generation particle accelerators and new cancer treatments.
　
The results, published online August 19 in Nature Physics, also confirm predictions made more than 60 years ago about the fundamental physics of laser-plasma interaction. Plasmas dense with electrons normally reflect laser light like a mirror. But a strong laser can drive those electrons to near the speed of light, making the plasma transparent and accelerating the plasma ions.
　
"That idea has been met with some skepticism in the field," said Rahul Shah of LANL’s plasma physics group. "We think that we’ve settled that controversy."
　
The team, which also included researchers from the Max Planck Institute for Quantum Optics in Garching, Germany and Queens University in Belfast, UK, used the 200 trillion-watt short-pulse TRIDENT laser at Los Alamos National Laboratory to observe the transparency phenomenon at 50 femtosecond resolution. Until now, those dynamics have been witnessed only in computer simulations.
　
The team found close agreement between the model and their experiments, which confirms what Los Alamos National Laboratory scientists have long suspected—that directing a short-pulse laser at a very thin carbon foil target will make the foil transparent to the laser.
　
"In a sense it also validates the simulation code that researchers have been using for some time," said Sasi Palaniyappan of LANL’s plasma physics group. "At the same time it also tells us that we’re doing an experiment that’s as close as possible to simulation."
　
The results will help advance work to control the shape and timing of laser pulses, precision that is necessary for developing next-generation, laser-driven particle accelerators, he said. The researchers have recently been awarded internal laboratory funding from the office of Laboratory Directed Research and Development (LDRD) to pursue these applications.
　
They now plan to add a second foil target, which could benefit from further focusing and faster turn-on of the laser light transmitted through the first foil. One application of the resulting ultra-short ion bunches is to rapidly heat material and study the ensuing dynamics.
　
Particles accelerated by conventional accelerators aren’t fast enough for such physics experiments. Also, energetic ions are applicable to cancer therapy. A more compact, laser-driven ion source would make treatment less expensive and more accessible to patients.
　
This work was sponsored by the Los Alamos National Laboratory Directed Research and Development program, U.S. Department of Energy, the U.S. Office of Fusion Energy Sciences and the U.S. Domestic Nuclear Detection Office. The paper is titled "Dynamics of relativistic transparency and optical shuttering in expanding overdense plasmas."

STOPPING CANCER WITH A VACCINE

FROM:  U.S. DEPARTMENT OF DEFENSE ARMED WITH SCIENCE
Honduran Dr. Jose Mejia, left, and Col. George Peoples, Mobile Surgical Team, work together to perform surgery on a Honduran boy at Santa Teresa Hospital in Comayagua, Honduras. (By Air Force Staff Sgt. Bryan Franks) 

Written on MAY 4, 2012 AT 7:04 AM by JTOZER
Stopping Cancer Before It Starts
An Army doctor has helped develop a vaccine that he believes will prevent cancer, or at least its recurrence.

The drug NeuVax began phase III clinical trials Jan. 20, which Col. George Peoples said could lead to its Food and Drug Administration, or FDA, approval. Peoples is chief of surgical oncology at the San Antonio Military Medical Center when he’s not traveling the world to provide surgical expertise or working to try and find a cure for cancer.
He is currently deployed to Honduras.

The phase III clinical trial for NeuVax will involve at least 700 breast cancer patients at 100 sites in the United States and abroad. The trial is titled PRESENT, Prevention of Recurrence in Early-Stage, Node-Positive Breast Cancer with Low to Intermediate HER2 Expression with NeuVax Treatment.

Participants will receive one intradermal injection every month for six months, followed by a booster inoculation every six months thereafter. The primary endpoint is disease-free survival at three years.

“The first patient was vaccinated with NeuVax in January at San Antonio Military Medical Center, Fort Sam Houston, Texas,” Peoples said.
Peoples is the director and principal investigator for a Cancer Vaccine Development Program that he has been working on since the early 90s. The vaccine carries the generic name E75.

This third and final phase of testing before FDA approval will bring NeuVax one step closer to the market and to the breast cancer patients who need more options, Peoples said.

According to the Centers for Disease Control and Prevention, about 203,000 individuals in the United States are diagnosed with invasive breast cancer each year.

VACCINE MIGHT PREVENT OTHER CANCERS
Yes, there are ways to treat cancer, but why wait and treat, why not try to prevent? The desire to prevent disease, Peoples said, is what led to the eradication of smallpox and hopefully will lead to the eradication of polio.

“If you vaccinate enough people, you prevent the disease and it can no longer exist in the population; eventually it’s eradicated. So, if you believe that concept, then we need to figure out a way to prevent cancers, as opposed to detect them earlier or treat them better,” Peoples said.

He said one of the advantages of the new drug is the majority of cancers actually express some levels of the protein. It’s not exclusive to breast cancer, either, Peoples said.

TRULY PREVENTIVE VACCINE
A lot of times, he said, people actually do have cancer cells, or “cancer-esque” cells. It’s just they haven’t formed the cancer yet. And so those cells will theoretically be recognizable to the immune system, and can be affected by a vaccine.

“Ultimately, that is the goal – to provide a protective-type vaccine so that a person never actually develops the cancer,” Peoples said.

“So you could ultimately envision a vaccine that targets those critical proteins that are necessary for cancer to form. And if you have immunity, such that your body can recognize those proteins as soon as they show up, then theoretically, you could prevent a person from ever developing a cancer.”

“The good news is, I think those proteins are likely to be common proteins, shared among multiple cancer types,” he said.  “So, it wouldn’t be a cancer-specific vaccine, but a vaccine that would protect you against lung cancer, colon cancer, prostate cancer, etc.”

“I think that is theoretically possible, it’s just a matter of identifying the most useful antigens to target,” Peoples said.

CDC SAYS U.S. CANCER DEATH RATES ARE DECLINING

The graphs and following excerpt are from the Centers for Disease Control website:
Report to the nation finds continuing declines in cancer death rates since the early 1990s
Special feature highlights cancers associated with excess weight and lack of sufficient physical activity

Death rates from all cancers combined for men, women, and children continued to decline in the United States between 2004 and 2008, according to the Annual Report to the Nation on the Status of Cancer, 1975–2008. The overall rate of new cancer diagnoses, also known as incidence, among men decreased by an average of 0.6 percent per year between 2004 and 2008.  Overall cancer incidence rates among women declined 0.5 percent per year from 1998 through 2006 with rates leveling off from 2006 through 2008.

The report is co–authored by researchers from the Centers for Disease Control and Prevention, the North American Association of Central Cancer Registries, the National Cancer Institute, and the American Cancer Society. It appears early online in the journal CANCER, and will appear in print in the May issue.

The special feature section highlights the effects of excess weight and lack of physical activity on cancer risk. Esophageal adenocarcinoma, cancers of the colon and rectum, kidney cancer, pancreatic cancer, endometrial cancer, and breast cancer among postmenopausal women are associated with being overweight or obese. Several of these cancers also are associated with not being sufficiently physically active.

“This report demonstrates the value of cancer registry data in identifying the links among physical inactivity, obesity, and cancer,” said CDC Director Thomas R. Frieden, M.D. “It also provides an update of how we are progressing in the fight against cancer by identifying populations with unhealthy behaviors and high cancer rates that can benefit from targeted, lifesaving strategies, and interventions to improve lifestyle behaviors and support healthy environments.”

For more than 30 years, excess weight, insufficient physical activity, and an unhealthy diet have been second only to tobacco as preventable causes of disease and death in the United States.  However, since the 1960s, tobacco use has declined by a third while obesity rates have doubled, significantly impacting the relative contributions of these factors to the disease burden.  Excess weight and lack of sufficient physical activity have been linked to increased risk of cardiovascular disease, hypertension, diabetes, and arthritis, as well as many cancers.

“In the United States, 2 in 3 adults are overweight or obese and fewer than half get enough physical activity,” said John R. Seffrin, Ph.D., chief executive officer of the American Cancer Society. “Between children and youth, 1 in 3 is overweight or obese, and fewer than 1 in 4 high school students get recommended levels of physical activity. Obesity and physical inactivity are critical problems facing all states. For people who do not smoke, excess weight and lack of sufficient physical activity may be among the most important risk factors for cancer.”

The Report to the Nation was first issued in 1998. In addition to drops in overall cancer mortality and incidence, this year's report also documents the second consecutive year of decreasing lung cancer mortality rates among women. Lung cancer death rates in men have been decreasing since the early 1990s.

Colorectal cancer incidence rates also decreased among men and women from 1999 through 2008.  Breast cancer incidence rates among women declined from 1999 through 2004 and plateaued from 2004 through 2008.  Incidence rates of some cancers, including pancreas, kidney, thyroid, liver, and melanoma, increased from 1999 through 2008.

“The continued declines in death rates for all cancers, as well as the overall drop in incidence, is powerful evidence that the  nation's investment in cancer research produces life–saving approaches to cancer prevention, screening, diagnosis, and treatment,” said NCI Director Harold E. Varmus, M.D.  “But, it is also important to note that investments we make today are critical if we hope to see these declines in incidence and death from cancer reflected in future Reports to the Nation.”

Among children aged 19 years or younger, cancer incidence rates increased 0.6 percent per year from 2004 through 2008, continuing trends from 1992, while death rates decreased 1.3 percent per year during the same period. These patterns mirror longer–term trends.

Among racial and ethnic groups, the highest cancer incidence rates between 2004 and 2008 were among black men and white women. Cancer death rates from 2004 through 2008 were highest among black men and black women, but these groups showed the largest declines for the period between 1999 and 2008, compared with other racial groups. The differences in death rates by racial/ethnic group, sex, and cancer site may reflect differences in risk factors, as well as access to and use of screening and treatment.

“While the sustained decline in cancer mortality rates is good news, the persistence of disparities among racial and ethnic groups continues to concern us,” said Betsy A. Kohler, executive director of NAACCR. “The collection of comprehensive cancer surveillance data on all patients may provide clues to understanding these differences and addressing them.”

The report notes that continued progress against cancer in the United States will require individual and community efforts to promote healthy weight and sufficient physical activity among youth and adults.
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