NSF REPORTS ON RESEARCH SHOWING HOW BRAIN REGIONS INTERACTS

FROM:  NATIONAL SCIENCE FOUNDATION 

Researcher studies how different brain regions interact during tasks
2014 MacArthur Fellow’s work has potential to diagnose and treat Alzheimer’s disease, schizophrenia, addiction, stroke, autism, epilepsy and Parkinson’s disease

Danielle Bassett has an unusual take on studying the brain.

Bassett, the Skirkanich Assistant Professor of Innovation in the Department of Bioengineering at the University of Pennsylvania, a physicist by training, specializes in studying complex systems, that is, systems made up of individual pieces that interact with each other in complicated ways--materials, for example.

"When you look at the particles that make up materials, you can see the different forces that the particles are putting on each other," says the National Science Foundation (NSF)-funded scientist. "It looks like a web, or tree, with complicated loops. Looking at the forces from the inside, you can see the complicated networks."

She sees the brain similarly, as an example of an intricate system of connected interacting parts, including cells, neurons and other circuitry; thus, she is using the same tools with which she studies other complex systems to gain a better understanding of how the brain works. "Our approach focuses on the network level, which distinguishes our methods from traditional neuro-imaging," she says.

Using mathematical computer algorithms she and her collaborators developed, she studies how different brain regions interact with one another while someone is engaged in a task. The goal is to understand how this interaction enables individuals to think, perform tasks, interact with the environment, change their behavior, learn and retain information and hold on to memories.

"We develop analytic tools to probe the hard-wired pathways and transient communication patterns inside the brain to try to identify organizational principles, and develop novel diagnostics of disease," she says, with the idea ultimately of designing "personalized therapeutics for rehabilitation and treatment of brain injury, neurological disease and psychiatric disorders."

The work has the potential to affect diagnosis and treatment of such brain disorders as Alzheimer's disease, schizophrenia, addiction, stroke, autism, epilepsy and Parkinson's disease, possibly even allowing clinicians to identify these conditions--and intervene--earlier.

Bassett has received NSF grants that support her work, including an award to hold a May 2014 workshop on quantitative theories of learning, memory and perception, and a computational neuroscience award funding collaborative research with Fabio Pasqualetti, assistant professor of mechanical engineering at the University of California, Riverside. The latter is examining mapping and control of large scale neuro-circuitry, and noninvasive techniques to stimulate the brain.

Bassett also is a recent recipient of one of this year's prestigious MacArthur fellowships, a $625,000 no-strings-attached award, popularly known as a "genius" grant. These go to talented individuals who have shown extraordinary originality and dedication in their fields, and are meant to encourage beneficiaries to freely explore their interests without fear of risk-taking. She plans to use the money to advance her research.

Bassett's experiments involve using MRI technology to determine how brain circuits work together while learning a motor task, in this case, a series of finger movements similar to piano arpeggios. They perform them using a button box that resembles a keyboard.

"We want to see what happens when you learn how to move your body in a particular way," she says. "People come into the MRI and learn these over the course of six weeks, one session of 90 minutes every two weeks. We teach them six sequences at the beginning of the experiment, and they practice the same six over and over again."

Using brain imaging data of people learning this task over three distinct time periods, Bassett and colleagues found that they could predict a person's ability to learn based on the brain's flexibility, or the ability of different areas of the brain to connect in different combinations, and in identifying existing brain functions that come into play when learning a new behavior.

She found that people with more "flexible" brain networks learn better. She compares it to group dancing when explaining what she means by flexible.

"First you dance with one person, then you switch," she says. "The same thing happens in brain regions. The number of brain regions involved is equal to their flexibility; the more a brain region switches partners, the more flexible it is."

Thus far, the study has involved only young adults, but she hopes to conduct similar experiments on older people and children.

"I would expect kids to be more flexible, and older people to be less flexible," she says.

The hope is that the basic science ultimately will lead to brain stimulation techniques that will encourage the brain to become more flexible and, when injured, recover faster.

"For example, you could intervene after a stroke so someone can relearn and recuperate faster," she says. "That is our incentive, to determine whether we can use brain stimulation to enhance flexibility, quickening rehabilitation after injury."

-- Marlene Cimons, National Science Foundation
Investigators
Danielle Bassett
Mala Murthy
Nancy Kopell
William Bialek
Related Institutions/Organizations
University of Pennsylvania
Princeton University

MALE DNA IN THE FEMALE BRAIN

Credit:  Wikimedia.

FROM: U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES

Some Women's Brains Contain Male DNA: Study

Health implications are unclear, researchers say.

WEDNESDAY, Sept. 26 (HealthDay News) -- Male DNA and cells are commonly found in some women's brains and most likely come from male fetuses, according to a small new study.

The medical implications of male DNA and male cells in women's brains are unknown. Previous studies of microchimerism -- the presence of genetic material and cells that were exchanged between fetuses and mothers during pregnancy -- have linked it to autoimmune diseases and cancer in both helpful and harmful ways.

Researchers at the Fred Hutchinson Cancer Research Center in Seattle analyzed brain autopsy specimens from 59 women who died between the ages of 32 and 101. Male DNA was detected in 63 percent of the women and was distributed in various brain regions. The oldest woman with male DNA was 94.

Thirty-three of the 59 women in the study had Alzheimer's disease. These women had a somewhat lower prevalence of male DNA, which was present in lower concentrations in regions of the brain most affected by Alzheimer's.

Because of the small number of women in the study and their largely unknown pregnancy history, it is not possible to establish a link between Alzheimer's disease and levels of male DNA and cells from a fetus, the researchers said in a cancer center news release.

They also added that the study does not show an association between male microchimerism in women's brains and their health or risk of disease. Further research is needed to investigate this area.

The study was published Sept. 26 in the journal PLoS One.

OBAMA ADMINISTRATION INCREASES BY $100 MILLION FUNDING TO COMBAT ALZHEIMER'S

Photo: Kathleen Sebelius

FROM:  U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES

HHS Secretary Sebelius outlines research funding, tools for health care providers, awareness campaign and new website

Health and Human Services Secretary Kathleen Sebelius today released an ambitious national plan to fight Alzheimer’s disease. The plan was called for in the National Alzheimer’s Project Act (NAPA), which President Obama signed into law in January 2011. The National Plan to Address Alzheimer’s Disease sets forth five goals, including the development of effective prevention and treatment approaches for Alzheimer’s disease and related dementias by 2025.

In February 2012, the administration announced that it would take immediate action to implement parts of the plan, including making additional funding available in fiscal year 2012 to support research, provider education and public awareness. Today, the Secretary announced additional specific actions, including the funding of two major clinical trials, jumpstarted by the National Institutes of Health’s (NIH) infusion of additional FY 2012 funds directed at Alzheimer’s disease; the development of new high-quality, up-to-date training and information for our nation’s clinicians; and a new public education campaign and website to help families and caregivers find the services and support they need.

To help accelerate this urgent work, the President’s proposed FY 2013 budget provides a $100 million increase for efforts to combat Alzheimer’s disease. These funds will support additional research ($80 million), improve public awareness of the disease ($4.2 million), support provider education programs ($4.0 million), invest in caregiver support ($10.5 million), and improve data collection ($1.3 million).

“These actions are the cornerstones of an historic effort to fight Alzheimer’s disease,” Secretary Sebelius said. “This is a national plan—not a federal one, because reducing the burden of Alzheimer’s will require the active engagement of both the public and private sectors.”

The plan, presented today at the Alzheimer’s Research Summit 2012: Path to Treatment and Prevention, was developed with input from experts in aging and Alzheimer’s disease issues and calls for a comprehensive, collaborative approach across federal, state, private and non-profit organizations. More than 3,600 people or organizations submitted comments on the draft plan.

As many as 5.1 million Americans have Alzheimer’s disease and that number is likely to double in the coming years. At the same time, millions of American families struggle with the physical, emotional and financial costs of caring for a loved one with Alzheimer’s disease.

The initiatives announced today include:

• Research – The funding of new research projects by the NIH will focus on key areas in which emerging technologies and new approaches in clinical testing now allow for a more comprehensive assessment of the disease. This research holds considerable promise for developing new and targeted approaches to prevention and treatment. Specifically, two major clinical trials are being funded. One is a $7.9 million effort to test an insulin nasal spray for treating Alzheimer’s disease. A second study, toward which NIH is contributing $16 million, is the first prevention trial in people at the highest risk for the disease.
• Tools for Clinicians – The Health Resources and Services Administration has awarded $2 million in funding through its geriatric education centers to provide high-quality training for doctors, nurses, and other health care providers on recognizing the signs and symptoms of Alzheimer’s disease and how to manage the disease.
• Easier access to information to support caregivers–HHS’ new website, www.alzheimers.gov, offers resources and support to those facing Alzheimer’s disease and their friends and family. The site is a gateway to reliable, comprehensive information from federal, state, and private organizations on a range of topics. Visitors to the site will find plain language information and tools to identify local resources that can help with the challenges of daily living, emotional needs, and financial issues related to dementia. Video interviews with real family caregivers explain why information is key to successful caregiving, in their own words.
• Awareness campaign – The first new television advertisement encouraging caregivers to seek information at the new website was debuted. This media campaign will be launched this summer, reaching family members and patients in need of information on Alzheimer’s disease.

Today’s announcement demonstrates the Obama administration’s continued commitment to taking action in the fight against Alzheimer’s disease.

In 2013, the National Family Caregiver Support Program will continue to provide essential services to family caregivers, including those helping loved ones with Alzheimer’s disease. This program will enable family caregivers to receive essential respite services, providing them a short break from caregiving duties, along with other essential services, such as counseling, education and support groups.

For more information on the national plan to address Alzheimer’s disease, visit: www.alzheimers.gov.